qfromq3.txt

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Author:
arimoses
ID:
150158
Filename:
qfromq3.txt
Updated:
2012-04-25 19:39:18
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qfromq
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uworld qfromq 4/25/12
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  1. What enzyme is specific for mast cells and used as a marker for anaphylaxis (mast cell activation)?
    Tryptase.
  2. Cross linking of IgE receptors from antigen results in what?
    Receptor aggregation -> degranulation.
  3. What side effect is characteristic to digoxin toxicity, what side effect is fatal?
    • Disturbed color perception
    • Also: Nausea, vomiting, anorexia, diarrhea
    • Fatal: Ventricular tachyarrythmias.
  4. What is the name for the biologically active form of pantothenic acid?
    Coenzyme A.
  5. Which picornavirus is acid labile?
    Rhinovirus.
  6. Which beta blocker also has class 3 (K channel) effects?
    Sotalol.
  7. What murmur is accentuated by the hand-grip exercise (increased afterload)?
    VSD.
  8. Neurofibromas of NF are derived from what embryological structure?
    Neural crest cells.
  9. Insulin acts via tyrosine kinase receptors to increase activity of which intracellular enzyme?
    Protein phosphatase 1.
  10. What are the actions of protein phosphatase 1?
    • Dephosphorylates glycogen synthase -> activation -> increased glycogen synthesis
    • Dephosphorylates F-1,6-BP -> Deactivation -> decreased gluconeogenesis.
  11. What is another name for antibodies against neutrophil myeloperoxidase?
    perinuclear staining antineutrophil cytoplasmic antibodies (p-ANCA).
  12. MOA of raloxifene?
    • Agonist at bone and myocardium
    • Antagonist at breast and ovary.
  13. Hypoglycemia and low ketone levels following prolonged fasting?
    Deficiency of Acyl-CoA Dehydrogenase -- first step in b-oxidation of FFA.
  14. What do mucicarmine and methenamine silver stain for?
    Cryptococcus neoformans.
  15. Rituximab is an antibody against what antigen, used for what?
    • CD20
    • Lymphomas.
  16. Imatinib is used for?
    CML.
  17. What is interleukin-2 used for?
    Renal cell carcinoma and melanoma.
  18. What hormone prevents lactation despite high prolactin levels in pregnant women?
    Progesterone.
  19. What should be tested before beginning amiodarone therapy?
    TSH.
  20. Thayer martin medium is a culture used to select for what organism?
    Neisseria spp.

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