Digoxin PK

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Digoxin PK
2012-04-27 23:35:34

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  1. What are two uses for digoxin?
    • Heart failure
    • Atrial fibrillation and flutter
  2. What is the MOA of digoxin?
    • Positive inotropic: Inhibits Na/K-ATPase, Increases intracellular calcium --> Increases CO in HF due to systolic dysfunction
    • Negative chronotropic: Parasympathetic activity and vagal tone, shortens atrial contraction and prolongs AV nodal refractory period--> used in atrial fibrillation and flutter
  3. What is the bioavailability of the capsule dosage form of digoxin?
  4. What is the bioavailability of the tablet dosage form of digoxin?
  5. What is the bioavailability of the elixir dosage form of digoxin?
  6. If you need to change from IV to oral digoxin, how do you adjust the dose?
    Increase by 25%
  7. If you need to change from oral to IV digoxin, how do you adjust the dose?
    Decrease by 25%
  8. Where is the major site of absorption?
    Small intestine
  9. What factors can decrease absorption of digoxin?
    • High fiber meals (tablets and capsules)
    • Malabsorption syndromes
    • Chemotherapy and radiation
    • Drugs: Antacids, cholestyramine, metoclopramide
  10. What drugs can increase the absorption of digoxin?
    • Amiodarone
    • Verapamil
    • Quinidine
  11. Does digoxin have long or short distribution?
  12. What type of tissues does digoxin like?
    Lean organ tissues (muscle, heart, kidneys, and liver)
  13. What is the serum to cardiac tissue ratio for digoxin?
  14. What percentage of digoxin is protein bound?
  15. Does physical exercise increase or decrease the distribution of digoxin to skeletal and heart muscles?
  16. True or False: The Volume of Distribution of digoxin is affected by obesity.
  17. What are two things that can decrease the volume of distribution of digoxin?
    • Renal Failure
    • Hyperkalemia
  18. Where is the major site of metabolism for digoxin?
    GI tract
  19. What is a potential interaction between macrolides and digoxin?
    Digoxin is metabolized by E. lentum which may be eradicated with the use of macrolide antibiotics and therefore will increase the absorption of digoxin by 30%
  20. What are three ways that digoxin is metabolized?
    • 1. Hydrolyzed by stomach acid
    • 2. Liver (minor 3A4)
    • 3. Reduced by GI bacteria to inactive metabolites
  21. What percentage of digoxin is excreted unchanged via the kidneys?
  22. How is 25% of digoxin excreted?
    biliary and heptaic elimination
  23. What is the 1/2 life of digoxin?
    36 hours
  24. What are factors that decrease the clearance of digoxin?
    • Heart failure
    • Hypothyroidism
    • Verapamil
    • Amiodarone
    • Itraconzole
    • Hypokalemia
  25. What are factors that increase the clearance of digoxin?
    • Hyperthyroidism
    • Digoxin Immune fab (Digibind)
  26. What weight is used to calculate a digoxin dose?
    Ideal Body Weight
  27. What is the LD for oral digoxin?
    1-1.5 mcg
  28. What is the LD for IV digoxin?
    0.5-1 mcg IV
  29. How should a LD of digoxin be split?
    • 50% Initially
    • 25% at 6 hours
    • 25% at 12 hours
  30. True or False: A LD is typically not administered when treating HF.
  31. What is the MD of digoxin?
    0.125-0.5 mcg daily
  32. What is the therapeutic range of digoxin for CHF?
    0.5-1.0 mcg/L
  33. What is the therapeutic range of digoxin for AF?
    0.8-2.0 mcg/L
  34. When should you check digoxin levels?
    • Clinical deterioration
    • Assess compliance
    • Acute changes in renal function
    • Toxicity is suspected
    • New interaction (drug or condition)
  35. When should a level be drawn when given a LD?
    12-24 hours after the initial dose
  36. When should a level be drawn when the patient does not receive a LD?
    3-5 days
  37. Following IV MD, when should a level be drawn?
    • No sooner than 6 hours after dose
    • Or obtain a trough level before next dose
  38. If a digoxin dose is adjusted, when should serum concentration be drawn?
    5-7 days
  39. Although toxicity may occur at therapeutic concentrations, at what concentration is toxicity most often seen?
    > 2.0 mcg/L
  40. What are cardiac toxicites associated with digoxin?
    • Bradycardia
    • Atrial tachycardia with 2nd and 3rd degree AV block
    • Fatal ventricular arrhythmias
  41. What non-cardiac toxicites are associated with digoxin?
    • Blurred, yellow-green halo vision
    • GI: N/V/D, abdominal pain
    • CNS: headache, fatigue, confusion, vertigo
    • All due to inhibition of Na/K-ATPase
  42. What are the effects of digoxin with hypokalemia?
    Hypokalemia potentiates effects of digoxin
  43. What are the effects of calcium abnormalities on digoxin?
    Hypercalcemia facilitates toxicity
  44. What are the effects of magnesium abnormalities on digoxin?
    hypomagnesemia potentiates proarrhythmic effects
  45. How do you calculate how much digibind is needed to correct an overdose of digoxin?