BIO 370 E3 C7 P2

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shockwave
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BIO 370 E3 C7 P2
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2012-05-02 16:16:25
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BIO 370 E3 C7 P2
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BIO 370 E3 C7 P2 GSU 2012
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  1. Adherens junctions in epithelia forms a ______ around cell’s apical surface
    BELT
  2. WHATS ON THE EXTRACELLULAR AND INTRACELLULAR SIDE OF AN ADHEREN JUNCTION?
    • Extracellular domains of cadherin molecules.
    • Intracellular domains of cadherin are linked by catenins to cytoskeletal proteins.
  3. WHAT THE HELL IS THE DIFFERENCE BETWEEN CATENIN & CADHERIN.
    • CADHERIN EXTERNAL. CATENIN INTERNAL.
  4. NAME THE 4 INTERCELLULAR JUNCTIONS ON LATERAL SURFACES, FROM THE TOP DOWN.
    • GAO JUNCTION
    • ADHERENS JUNCTION
    • DESOSOMES
    • GAP JUNCTIONS
    • (HEMIDESMONDS CONNECT CELL TO SURFACE, HORIZONTIAL)
  5. NAME THE STRUCTURE & FUNCTION
    • DESMOSOMES. DISC SHAPED.
    • Adhesion receptors in transmembrane signaling
    • Binding of integrins and cadherins to extracellular ligands transfer information
    • Intracellular changes can influence: growth, differentiation or survival
  6. WHAT IS THE FUNCTION OF ALPHA-ACTININ?
    • IT COMBINES THE A & B ACTIN FILAMENTS OF ADHERENS JUNCTIONS TOGTHER IN THE CYTOPLASMA SIDE OF THE CELL.
  7. T OR F
    DESMOSOMES ARE DISC SHAPED JUNCTIONS BETWEEN CELLS, THEY DO NOT FORM A BELT AROUND THE CELL.
    TRUE
  8. WHAT DOES THE INTRACELLULAR DOMAIN OF A DESMOSOME CONSIST OF?
    LINKED TO INTERMEDIATE FILAMANTS THAT SPAN THE ENTIRE CELL.
  9. OF THE 4 TYPES OF LATERIAL CELL CONNECTIONS, WHICH WOULD BE INVOLED IN INTRACELLULAR CHANGES THAT CAN INFLUENCE GROWTH, DIFFERENTIATION OR SURVIVAL?
    DESMOSOMES
  10. WHAT IS THIS & NAME THE 7 STRUCTURES
    • GREEN: DESMOGLEN GRY: DESMOCOLLIN
  11. CATHEREIN & CATENINS ARE FOUND IN WHAT TYPE OF JUNCTION?
    ADHERE JUNCTIONS
  12. NAME THE 3 PROTEINS THAT MAKE THE PLATE OF THE DESMOSOME.
    • DESMOPLAKIN, PLAKGLOBIN &
    • CYTOPLASMIC PLAQUE
  13. CELLS ATTACH TO LIVING AND NON-LIVING SUBSTRATIUM, WHAT'S THE DIFFERENCES?
    • FOCAL ADHESION & HEMIDESMOSOME
    • KNOW EACH PROCESS!!!
  14. 5 types of interactions involving the cell surface
    • DESMOGLEIN TO DESMOCOLLIN (NOT IN PIC)
  15. Inflammation begins with a recruitment of leukocytes to the site of injury.
    Neutrophils attach to ________ on the walls of venules
    P-selectins
  16. ____ ______ _____ alters the binding of neutrophilic integrins to IgSF (ICAMs)
    PLATELET ACTIVATING FACTOR (PAF)
  17. DEFINE EXTRAVASATION
    • DURING INFLAMMATION, A NEUTROPHIL SLIP THRU THE VESSEL WALLS INTO TISSUE.
    • (THEN THEY BIND TO IgSF, WHICH ARE LOW-LEVEL, NON-SPECIFIC)
  18. T OR F
    NEUTROPHILS BIND TO NON SPECIFICALLY, UNLINKE T & B CELLS.
    TRUE
  19. NAME THE 4 Steps in movement of neutrophils from bloodstream during inflammation
  20. T OR F
    METASTATIC CELLS, AS A RESULT OF ABNORMAL CELL ADHERSION, ARE ABLE TO penetrate barriers like ECM, connective tissues and basement membranes lining blood vessels
    TRUE
  21. IF YOU REMOVED THE ECM FROM MAMMARY GLAND CELLS, WOULD IT FUNCTION?
    • NO.
    • CELL WOULDN'T GET ANY SIGNALS...NO INSTRUCTIONS...NO MILK.
  22. DEFINE TIGHT JUNCTION AND GIVE EXAMPLE
    • Continuous parallel strands of integral proteins encircle the cell.
    • Occurs between epithelial cells.
    • Tight junctions form the blood brain barrier.
    • (Immune cells (NEUTROPHLS) can get in via unknown signal)
  23. WHERE DOES ONE FIND Integral proteins (occludin)?
    TIGHT JUNCTIONS
  24. ANYTHING THAT IS OUTSIDE OF THE EPITHIAL CELL LAYER IS STILL OUTSIDE OF YOU.
    TRUE
  25. DEFINE THE PARACELLULAR PATHWAY.
  26. NAME 2 PROTEINS ASSOCIATED WITH THE STRUCTURE OF TIGHT JUNCTION
    OCCLUDIN (INTEGRAL) & CLAUDIN
  27. Mediating intracellular communication..WHAT JUNCTION?
    GAP
  28. WHERE DOES ONE FIND CONNEXONS?
    • GAP JUNCTIONS
    • Compatibility differences:Promoting or preventing communication.
    • Complex of 6 connexin molecules
    • Connexons have pores allowing diffusion of molecules
    • Less than 1000 daltons will pass through (LARGE SHIT)
  29. INTEGRATION OF ACTIVITY OF ADJACENT CELLS OCCURS AT WHAT JUNCTION?
    • GAP.
    • CHM WILL NOT JUST EFFECT A CELL, IT WILL EFFECT MANY OF THE SAME TYPES OF CELLS ATTACHED TO EACH OTHER.
  30. HYDRO______ CHANNEL IS FOUND INSIDE THE GAP JUNCTION CONNEXONS CHANNEL
    HYDROPHILLIC
  31. HOW MANY CONNEXONS IN A GAP JUNCTION FORMATION?
    6
  32. DEFINE GJIC
    • Gap junctions intercellular communication (GJIC)
    • integrates the activity of adjacent cells
  33. T OR F ?
    Many forms of cancer cells lack normal GJIC
    • TRUE
    • GJIC decreases progressively as some cancers grow
    • Defective genes encoding gap junctions may be involved in some types of cancer
  34. A rapid spread of depolarization between adjacent cells.. what junction is responsible?
    gap junction.
  35. DEFINE Plasmodesmata
    • channels through cell walls connecting adjacent plant cellsMuch different structure that gap junctions.
  36. GAP JUNCTION EQUIVILANT IN PLANTS
    Plasmodesmata OR ROSETTES
  37. WHERE IN THE HELL DO YOU FIND ANNULUS?
    • Plasmodesmata.
  38. THE CELL WALL OF A PLANT CONSIST OF WHAT?
    Microfibrils of cellulose (GLUCOSE).

    The Matrix of the cell wall contains:Hemicellulose, pectins, and hydroxyproline-rich, proline rich, and glycine rich structural proteins
  39. CELL WALL GRORTH STAGES ARE.....
    EARLY: Primary cell walls are flexible: Allow growth after division.

    LATE: Mature secondary cell walls:Thicker and more rigid
  40. WHAT THE HELL IS THIS?
    • Cellulose microfibrils. PLANT WALL.
    • THINK FENCE, NOT WALL. A MEMBRANE IS MORE LIKE A WALL.
  41. Tunneling Nanotubes; Cells pass materials from cell to cell via ________ supported processes.
    ACTIN
  42. WHERE IN THE HELL DOES ONE FIND A ROSETTE?
    • PLANT
  43. Cellulose fibril deposition: each rosette forms single _______ that associate________ and in orientation with underlying as they grow. WHERE ARE THE MICROFIBRIL OF THE ROSETTE IN RELATION TO THE CYTOPLASMA?
    • microfibril, laterally, microtubules (FORM CELL WALL)
    • MICROFIBRIL IS OUTSIDE.
  44. WHERE DOES THE SYNTHESIS OF PLANT CELL WALL OCCUR
    • ROSETTES.
    • GLUCOSE AND CELLULOSE SYNTHASE FOLLOW THRU THEM TO MAINTAIN TURGOR PRESSURE.
  45. Which of the following is not an example of a type of extracellular matrix?
    A. basement membrane
    B. intermediate filaments
    C. bone
    D. the cornea of the eye
    B. intermediate filaments
    (this multiple choice question has been scrambled)
  46. Which of the following proteins of the ECM has a membrane bilayer-spanning domain?
    A. fibrillar collagen
    B. heparan sulfate proteoglycans
    C. fibronectin
    D. laminin
    B. heparan sulfate proteoglycans
    (this multiple choice question has been scrambled)
  47. Embryos injected with antibodies to fibronectin show inhibited movement of neural crest cells during development of the nervous system. These experiments show that.....
    neurons in embryos must transiently bind to fibronectin during migration.
  48. Although the protein families that comprise the ECM are very different, they have one characteristics in common..WHAT THE HELL COULD IT BE?
    They all have two or more distinct domains with specific binding sites.
  49. Which of the following is not a role of integrins?
    A. Integrins anchor cells to the substrate.
    B. Integrins transmit signals to the intracellular compartment. D. Integrins participate in specialized cell-to-cell adhesive structures
    C. Integrins form a loose, hydrated gel in the ECM.
    C. Integrins form a loose, hydrated gel in the ECM.
    (this multiple choice question has been scrambled)
  50. Integrin is to a focal adhesion as _____is to an adherens junction.
    A. integrin
    B. selectin
    C. fibronectin
    D. cadherin
    cadherin
  51. The addition of a peptide with an RGD sequence would probably________ the binding of cultured cells to a fibronectin-coated dish.
    A. enhance
    B. inhibit
    C. have no effect on
    D. none of the above
    B. inhibit
    (this multiple choice question has been scrambled)
  52. The addition of a peptide with an RGD sequence would probably_____ the binding of cultured cells to a collagen-coated or laminin-coated dish.
    A. enhance
    B. inhibit
    C. have no effect on
    D. none of the above
    C. have no effect on
    (this multiple choice question has been scrambled)
  53. Focal adhesions are to cultured cells as__ are to cells in vivo.
    A. gap junctions
    B. hemidesmosomes
    C. plasmodesmata
    D. cell walls
    B. hemidesmosomes
    (this multiple choice question has been scrambled)
  54. a laboratory mouse had a mutation rendering the gene that codes for the L-selectin protein nonfunctional, which of the following symptoms would the animal exhibit?
    A. blistering of the skin
    B. clotting deficiencies
    C. metastasis
    D. inability to fight infection in the tissues
    inability to fight infection in the tissues
  55. Actin filaments are to focal adhesions as _____are to hemidesmosomes.
    A. myosin filaments
    B. keratin filaments
    C. microfilaments
    D. cadherins
    keratin filaments
  56. Calcium-dependent adhesion is to the cadherins as calcium-independent adhesion is to the______.
    A. fibronectins
    B. IgSF proteins
    C. glycocalyx
    D. integrins
    B. IgSF proteins
    (this multiple choice question has been scrambled)
  57. How might anti-selectin antibodies act as anti-inflammatory drugs?
    Anti-selectin antibodies prevent neutrophils from transiently binding vessel walls.
  58. Plasmodesmata of plant cells have _____ in common with gap junctions in animal cells, but have _____that gap junctions lack.
    cytoplasmic continuity, desmotubules
  59. DESMOTUBULE & ANNULUS.WHAT STRUCTURE ARE YOU TALKING ABOUT?
    Plasmodesmata.
  60. Fluorscein that is injected into one plant cell _____show up in adjacent cells; DNA injected into one plant cell ______show up in adjacent cells.
    • WOULD
    • WOULD NOT
  61. That cancer cells often lack the gap junctions common to non-malignant cells of the same type is evidence that.....
    GJIC is an element of controlled cell growth.
  62. What kind of cell-to-cell junctions would you expect to find in heart tissue?
    GAP JUNCTION
  63. FUNCTIONS OF THE JUNCTION
    • TIGHT..INBOUND MTLS
    • ADHERIN...ADHERSION
    • DESMOSOME...COMMUNICATION
    • GAP....TRANSPORT

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