Home > Flashcards > Print Preview

The flashcards below were created by user ch.tyrrell on FreezingBlue Flashcards. What would you like to do?

  1. Identify the peak concentrations for Gentamicin and Tobramycin based on diagnosis.
    • 2-4 mcg/ml: uncomplicated lower UTI
    • 4-5 mcg/ml: gram+ endocarditis (synergistic w/ penicillin)
    • 6-8 mcg/ml: gram- infections (ex: sepsis)
    • 8-10 mcg/ml: gram- pneumonia
    • 10-12 mcg/ml: gram- pneumonia in pt w/ cystic fibrosis
  2. What is the trough concentration of gentamicin and tobramycin?
    < 1-2 mcg/ml
  3. Identify the peak concentrations of Amikacin based on diagnosis.
    • 20-30 mcg/ml: gram- infections (ex: sepsis)
    • 25-35 mcg/ml: gram- pneumonia
  4. What is the trough concentration Amicakin?
    < 5-10 mcg/ml
  5. When should aminoglycoside peaks and troughs be drawn?
    Peak: 30-60 min after a 30 minute infusion; 15 min after the end of a 60 min infusion

    Trough: 30 min or less prior to next dose
  6. What are the adverse effects and toxicities associated with aminoglycosides?
    • Nephrotoxicity
    • Neurotoxicity
    • Ototoxicity
  7. Describe the effects of nephrotoxicity associated with aminoglycoside toxicity.
    • may occur w/in 4-5 days (usually takes 5-10 days)
    • highest risk w/ duration > 10 days
    • usually nonoliguric
    • reversible in most cases
    • similar risk w/ gent/tobra/amikacin
    • average incidence ~20% (range 0-56%)
    • risk factors: age, other dz states, other nephrotoxic drugs
  8. Describe the effects of neurotoxicity associated with aminoglycosides.
    • muscle twitching
    • numbness
    • seizures
    • tingling
  9. Describe the effects of ototoxicity associated with aminoglycosides.
    • clinical incidence 0.5-3%
    • damage to 8th cranial nerve
    • may be unilateral or bilateral
    • onset is variable
    • cochlear (auditory): loss of hearing, tinnitus, feeling of ear fullness; often irreversible
    • vestibular: vertigo, ataxia, nystagmus, dizziness, n/v, unsteadiness; often irreversible
  10. When should a loading dose of aminoglycosides be used?
    When CrCl is < 30 ml/min
  11. What patient weight should be used for CrCl, Vd and dose when dosing aminoglycoside?
    CrCl = TBW

    Vd = IBW

    Dose = IBW

    **Use Adjusted BW if patient is obese**
  12. What are the extended interval aminoglycoside dosing values for gentamicin/tobramycin and amikacin?
    Gentamicin/Tobramycin: 7mg/kg

    Amikacin: 15 mg/kg
  13. How should initial interval dosing of aminoglycosides be determined?
    • 1. Calculate weight based dose
    • 2. Creatinine clearance determines the dosing interval

    ex: > 60ml/min = q 24h dosing

Card Set Information

2012-04-28 17:45:28
Aminoglycosides Lec

Show Answers:

What would you like to do?

Home > Flashcards > Print Preview