Amyloidosis

Card Set Information

Author:
manjinder
ID:
150741
Filename:
Amyloidosis
Updated:
2012-04-28 17:00:29
Tags:
pathology
Folders:

Description:
amyloid protein markers
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  1. Amyloidosis principle
    • misfolded protein deposited in extracellular space
    • b-plated sheet configuration
    • congo red staining and apple-green birefringence under polarized light
    • need biopsy for diagnosis
    • damaged organs must be transplanted since amyloid cannot be removed
  2. Multiple myeloma
    Systemic amyloidosis
    AL amyloid derived from immunoglobulin light chain
  3. chronic inflammation, malignancy, familial mediterranean fever
    systemic amyloidosis
    • AA amyloid which is derived from serum amyloid-associated protein (acute phase reactant)
    • FMF is due to a dysfunction of neutrophils

    Nephrotic syndrome, restrictive cardiomyopathy, tongue enlargement, malabsorption, hepatosplenomegaly
  4. Senile cardiac amyloidosis
    localized amyloidosis
    non-mutated serum transthyretin
  5. Familial amyloid cardiomyopathy
    localized amyloidosis
    • mutated serum transthyretin
    • restrictive cardiomyopathy
  6. Non-insulin-dependent diabetes mellitus (typeII)
    localized amyloidosis
    Amylin deposits in the islets of the pancreas
  7. Alzheimer disease
    localized amyloidosis
    • Abeta amyloid derived from beta-amyloid precursor protien
    • brain
    • present on chromosome 21. Down sydrome individuals develop Alzheimer by the age of 40
  8. dialysis- associated amyloidosis
    localized amyloidosis
    beta2- microglobulin (structural part of MHC I) deposits in joints
  9. Medullary carcinoma of the thyroid
    localized amyloidosis
    calcitonin (produced by tumor cells) deposits within the tumor (tumor cells in an amyloid background)

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