translation and people

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translation and people
2012-04-28 20:26:17

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  1. protien sysnthesis
    sequence of codons (AAA) on mRNA determine sequence of amino acids in protien being synthesized
  2. sense codes
    61 amino acids
  3. stop codons
    • 3
  4. start codon
  5. ribosome
    • site of translation
    • direct the orderlt bindin of tRNA to codon and assembly of amino acids to make protiens
    • move along mRNA in a 5'-3' direction
  6. tRNA
    recognize specific codon and transport amino acids
  7. translation steps
    • ribosom tRNA(UAC) and mRNA(AUG) come together
    • psite
    • a site
    • esite
    • peptide bonds cont
  8. p site
    where the first tRNA sits
  9. a site
    second codon of mRNA pairs with tRNA carrying amino acid- joined by peptide bonds
  10. ribsome moves
    along the mRNA
  11. e site
    first trna is in the esite
  12. second and thrid amino acid
    • joined by a peptide bond
    • 3 and 4, 4 and 5 and so on
    • until ribosome reaches stop codon
  13. stop codon
    • polypeptide released
    • ribosome comes apart tRNA released and polypeptide becomes a new protien
  14. mendel
    • 1865 studied pure breeding in pea plants
    • interested in genetics
  15. sutton
    • meiosis in grasshoppers
    • observed chromosomes separate hereditary material during meosis
  16. morgan
    • used fruit flies to develop genetics and discovered sex-linkage
    • students developed techniques of mapping genes on chromosomes
  17. griffith
    • discoverd transformation
    • genetic transfer in microorganisms
    • nonpathogenic strain is transformed into a thogenic strain and killed the rat
    • living nonencapsulated and heat killed encapsulated bacteria caused the diseasd
  18. genetic recombination
    exchange of genes between two dna molecules to form more combiations of genes on a chromosome
  19. delbruck
    develpoed and taught biologists methods to analyze bacteriophage; virus of bacteria
  20. deadie and tatum
    • develped neurospora -experimental organism
    • 1 gene 1enzyme hypothesis
  21. tatum and lederburg
    discovered conjugation in bacteria
  22. meischer
    • isolated DNA from the nuclei of cells obtained frm pus of surgical bandages
    • contained nitrogenous chemicals, sugar and phosphate
  23. avery and maclead
    • found transforming factor to be DNA by using enzymes
    • capsule-carbohydrase-transformation
    • protien-protease-transformation
    • rna-rnase-transformation
    • not dna DNAase
  24. hershey and chase
    • used 35s (protien)
    • 32p (nucleic acid)- went into cells
  25. watson and crick
    • xray cystallography to study DNA
    • made a model of dna
    • infered fuction leading o central dogma