Card Set Information
Which class of drug has good placental penetration?
Which class of drug does not undergo CYP450 elimination?
Which class of drug is renally eliminated?
What class of drug is Efavirenz ,which should be taken on an empty stomach as (high fat meals increase the aborption)
What class of drug is Rilpivirine, the drug that needs >500 calorie meal for adequate absorption?
Which class of drug uses extensive CYP450 metabolism and has a long half-life (up to 30-50 hours)
Which class of drug is a substrate of P-gp and CYP-3A4, has high first pass metabolism and low bioavailability, and included Atazanavir which needs acid for absorption?
Which class of drugs is Enfuvirtide in?
Which class of drug is Maraviroc, which is a substrate of P-gp and CYP450?
Which class of drug is Raltegravir, a drug that is eliminated by glucuronidation.
What happens when NNRTIs are given with statins?
NNRTIs decrease the concentration of statins therefore may need to be more aggressive with statin doses
What happens when Tenofovir is given with Atazanavir?
Atazanavir concentration is decreased and should always be boosted with ritonavir if given together
What happens when PIs are given with rifampin or St. John's Wort?
They both decrease the concentration of the PI and are contraindicated
What kind of interaction do PIs have with lovastatin/simvastatin?
PIs increase the concentration of lovastatin/simvastatin and are contraindicated with PIs
What is the maximum daily dose of omeprazole in patients taking PIs?
20mg per day
avoid PPIs in experienced pts
always boost with RTV
Which statins are preferred for a patient taking PIs?
pravastatin or atorvastatin b/c PI's increase the concentration of statins