PK

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Author:
ch.tyrrell
ID:
150934
Filename:
PK
Updated:
2012-04-29 16:39:38
Tags:
Antiretrovirals 11
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Description:
Antiretrovirals
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  1. Which class of drug has good placental penetration?
    NRTI
  2. Which class of drug does not undergo CYP450 elimination?
    NRTI
  3. Which class of drug is renally eliminated?
    NRTI
  4. What class of drug is Efavirenz ,which should be taken on an empty stomach as (high fat meals increase the aborption)
    NNRTI
  5. What class of drug is Rilpivirine, the drug that needs >500 calorie meal for adequate absorption?
    NNRTI
  6. Which class of drug uses extensive CYP450 metabolism and has a long half-life (up to 30-50 hours)
    NNRTI
  7. Which class of drug is a substrate of P-gp and CYP-3A4, has high first pass metabolism and low bioavailability, and included Atazanavir which needs acid for absorption?
    PIs
  8. Which class of drugs is Enfuvirtide in?
    fusion inhibitors
  9. Which class of drug is Maraviroc, which is a substrate of P-gp and CYP450?
    CCR5 inhibitors
  10. Which class of drug is Raltegravir, a drug that is eliminated by glucuronidation.
    Integrase inhibitors
  11. What happens when NNRTIs are given with statins?
    NNRTIs decrease the concentration of statins therefore may need to be more aggressive with statin doses
  12. What happens when Tenofovir is given with Atazanavir?
    Atazanavir concentration is decreased and should always be boosted with ritonavir if given together
  13. What happens when PIs are given with rifampin or St. John's Wort?
    They both decrease the concentration of the PI and are contraindicated
  14. What kind of interaction do PIs have with lovastatin/simvastatin?
    PIs increase the concentration of lovastatin/simvastatin and are contraindicated with PIs
  15. What is the maximum daily dose of omeprazole in patients taking PIs?
    • 20mg per day
    • avoid PPIs in experienced pts
    • always boost with RTV
  16. Which statins are preferred for a patient taking PIs?
    pravastatin or atorvastatin b/c PI's increase the concentration of statins

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