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Immunocytic system / specific
- Monocyte and macrophages
- Circulating T and B lymphocytes
What is a Band neutrophil appearance
- Nucleus is horseshoe shaped with large round ends
1.Phagocytic system / non-specific
Phagocytic system of leukocytes
Toxic neutrophil appearance
- •Blue cytoplasm
- •Dohle bodies in the cytoplasm (small angular blue-gray granules)
- •Vacuoles in the cytoplasm
- •Increased size
- •Could indicate bacterial infection
A Predominant circulating granulocyte is a
What is a neutrophil capable of doing?
Capable of seeking out, ingesting, killing, and digesting invading microorganisms
Eosinophils (a granulocyte
- •Red cytoplasmic granules
- •Modulate hypersensitivity reactions
- •Adhere to helminth parasites
- •Eosinophilia is only significant when it persists over time (several samples)
What kind of Granules do Neutophil contain?
•Contain specific granules (for bacterial killing) and lysosomes (with digestive enzymes)
Persistent eosinophilia is suggestive of systemic hypersensitivity reaction
True or False?
True or False
Neutrophils cannot divide, replenish granule content, or regenerate surface membrane ?
- They cannot divide, replenish granule content, or regenerate surface membrane
what is the lifespan of Neutrophils
Short life span of hours to days
Can only consider a sign of parasitic infection with parasites that have a systemic phase
True Or False?
- •Can only consider a sign of parasitic infection with parasites that have a systemic phase
What is a band cell?
Immature neutrophil, young cell
Is a left shift clinically important?
yes, Left shift is clinically important.
Neutrophilia with a left shift
classic acute inflammation
Neutropenia with a left shift
indicates overwhelming inflammation
Normal neutrophil counts do accompany what?
- •Irregular and elongated nucleus
- •Pale pink cytoplasm
Are Eosinopenia difficult to appreciate and diagnose?
Yes they are
- •Uniform in size and stain an intense pink
- Granules stain blue
- •Appear to have small vacuoles in the nucleus (those are the basophilic granules)
Are Basophils Phagocytic?
Not phagocytic, but do play a part in inflammation
What do Basophil granules contain?
Granules contain histamine (increase vascular permeability) and heparin (anticoagulant
When do Basophilia usually occur?
Basophilia usually occurs with eosinophilia
- •Similar nucleus to monocytes
- •Granules actually stain purple (possibly lavender) to blue-black
precursors of all macrophages
What do Macrophages do?
Macrophages are phagocytes, modify antigens for recognition, release inflammatory mediators, and regulate iron stores.
True or False Monocyte is not in circulation?
- Monocyte is in circulation!
Is macrophage in circulation?
No macrophage is not in circulation.
What does Monocytosis indicate?
Monocytosis indicates tissue necrosis and a demand for phagocytosis (acute or chronic)
What do Monocytes and Macrophages do of the Phagocytic system?
Links nonspecific and specific immune systems.
- •Variably shaped nuclei
- •Cytoplasm is blue-gray and may contain vacuoles and/or small fine pink granules
- •May be difficult to distinguish from band neutrophils
- •If there is no left shift you are probably looking at monocytes
- •Slightly indented nucleus
- •Cytoplasm is light blue and scanty
- •Cytoplasm may contain pink-purple granules
What is a Reactive Lymph & the appearance?
- Increased cytoplasm
- •Basophilic cytoplasm
- •Perinuclear halo
- Result of antigenic stimulation