Patho Pharm

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Author:
Rhenea
ID:
151034
Filename:
Patho Pharm
Updated:
2012-04-29 23:43:07
Tags:
Diabetic Med Insulin
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Description:
Diabetic Med's and Insulin
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  1. Meglitinides
    • Repaglinide (Prandin)
    • Nateglinide (Starlix)
  2. Sulfonylureas
    Second generation: GEN - IDE
    • Amaryl (glimepiride)
    • Glucotrol (glipizide)
    • Diabeta (glyburide)
  3. Biguanides
    Metformin - Glucophage
  4. Thiazolidinediones
    • Pioglitazone (Actos),
    • Rosiglitazone (Avandia)
    • Also known as “glitazones”
  5. Amylin Mimetics - Sub Q
    Pramlintide Symlin
  6. Incretin Mimetic - Sub Q
    Byetta
  7. Alpha-glucosidase inhibitors
    • Acarbose (Precose)
    • Miglitol (Glyset)
  8. Rapid Onset
    • Insulin aspart (Novolog)
    • Insulin lispro (Humalog)
    • Insulin glulisine (Apidra)
  9. Short Acting -Regular
    • Humulin R,
    • Novolin R,
  10. Intermediate -Acting
    • Isophane insulin suspension (also called NPH)
    • (Humulin N, Novolin N)
    • Insulin zinc suspension (also called Lente)
    • (Humulin L, Novolin L)
  11. Long-Acting
    • Glargine (Lantus) Zinc Suspt.
    • Ultralente, Humulin U
  12. Amaryl (glimepiride)
    Glucotrol (glipizide)
    Diabeta (glyburide)
    On set/Duratoin
    • Onset 1 - 1 ½ Hrs.
    • Duration 10-24Hrs.
  13. Repaglinide (Prandin) Nateglinide (Starlix)
    Onset/Duration
    • Onset 30 MIN
    • Duration < 4 Hrs
  14. Metformin - Glucophage
    Onset/Duration
    • Onset - 30 MIN
    • Duration - 6-20 Hrs.
  15. Pioglitazone (Actos),
    Rosiglitazone (Avandia) Also known as “glitazones”
    Onset/Duration
    • Onset - Unknown
    • Duration - 16-24 Hrs.
  16. Pramlintide Symlin
    Onset/Duration
    • Onset - 60 min
    • Duration - Unknown
  17. Byetta
    Onset/Duration
    • Onset - 60 min
    • Duration - Unknown
  18. Acarbose (Precose)
    Miglitol (Glyset)
    Onset/Duration
    • Onset - With Meals
    • Duration - Unknown
  19. Insulin aspart (Novolog)
    Insulin lispro (Humalog)
    Insulin glulisine (Apidra)
    Onset/Duration
    • Onset - 5-15Min
    • Duration - 3-5 Hrs.
  20. Humulin R,
    Novolin R,
    Onset/Duration
    • Onset - 30-60 Min
    • Duration - 6-10 Hrs.
  21. Isophane insulin suspension (also called NPH)
    (Humulin N, Novolin N)
    Insulin zinc suspension (also called Lente)
    (Humulin L, Novolin L)
    Onset/Duration
    • Onset - 1-2 Hrs.
    • Duration - 10-18 Hrs.
  22. Glargine (Lantus) Humulin L
    Ultralente, Humulin U
    Onset/Duration
    • Glargine (Lantus) Humulin L Onset - 1 Duration - 24+
    • Ultralente, Humulin U Onset - 6-10Hrs. Duration - 20-24Hrs.
  23. Amaryl (glimepiride)
    Glucotrol (glipizide)
    Diabeta (glyburide)
    Action / Side Effects
    • ACTION: Stimulate insulin secretion from beta cells of pancreas Beta cell function must be present for these drugs to work Improve sensitivity to insulin in tissues Result: Lower blood glucose levels First-generation drugs not frequently used
    • SIDE EFFECTS: Hypoglycemia, hematologic effects, nausea, epigastric fullness, heartburn, many others
  24. Repaglinide (Prandin) Nateglinide (Starlix)
    Action/Side Effects
    • ACTION: similar to sulfonylureas Increase insulin secretion from pancreas *most* effective within one hour of taking
    • SIDE EFFECTS: Headache, hypoglycemic effects, dizziness, weight gain, joint pain, URI or flu-like symptoms
  25. Metformin Glucophage
    Action/Side effects
    • ACTION: Do not give if NPO – Food Available soon inhibits liver and production Decrease production of glucose Increase uptake of glucose by tissues Does NOT increase insulin secretion from pancreas (does not cause hypoglycemia)
    • SIDE EFFECTS: Primarily affects GI tract: abdominal bloating/fullness, nausea, cramping, diarrhea May also cause metallic taste, reduced vitamin B12 levels (form of pernicious anemia) Lactic acidosis is rare, lethal if it occurs.
  26. Pioglitazone (Actos), Rosiglitazone (Avandia) Also known as “glitazones”
    Action/ Side Effects
    • ACTION: Genetic developer - Decrease insulin resistance, Are known as “insulin sensitizing drugs” Increase glucose uptake and use in skeletal muscle Inhibit glucose and triglyceride production in liver
    • SIDE EFFECTS: Moderate weight gain, edema, mild anemia Hepatic toxicity – monitor ALT levels closely
  27. Amylin Mimetics - Sub Q
    Action/Side effects
    • ACTION: Decreases postprandial plasma glucose levels. Slows gastric emptying, suppresses glucgon secretions and hepatic glucose production, increases satiety (sense of having eating enough)
    • SIDE EFFECTS: N/V/D/Anorexia, HA
  28. Byetta
    Action/Side effects
    • ACTION: Stimulate insulin secretion from beta cells of pancreas Reduce postprandial glucagon production. Slow gastric emptying. Increases satiety. Take 60 min prior to meal
    • SIDE FFECTS: N/V/D
  29. Amaryl (glimepiride)
    Glucotrol (glipizide)
    Diabeta (glyburide)
    Indications
    Lowers Blood sugar
  30. Repaglinide (Prandin)
    Nateglinide (Starlix)
    Indications
    Lowers Blood sugar
  31. Metformin Glucophage
    Indications
    decrease the production of glucose in the liver -
  32. Pioglitazone (Actos)
    Rosiglitazone (Avandia) Also known as“glitazones”
    Indications
    Glycogen glycogenesis decreases triglycerideshypertension- helps with Lipitor
  33. Pramlintide Symlin
    Indications
    Insulin's Rapid or Short acting dose should be reduced by 50%. Can delay absorption of any drugs taken
  34. Byetta
    Indications
    prevent insulin absorbation
  35. Acarbose (Precose)
    Miglitol (Glyset) enzyme blocker
    Indications
    Slows gastric absorbtion delaying absorbation of glucose.
  36. Insulin aspart (Novolog)
    Insulin lispro (Humalog)
    Insulin glulisine (Apidra)
    Indications
    Insulin replacement
  37. Humulin R
    Novolin R
    Indications
    Insulin replacement
  38. Isophane insulin suspension (also called NPH)
    (Humulin N, Novolin N)
    Indications
    Insulin replacement
  39. Insulinzinc suspension (also called Lente)
    (Humulin L, Novolin L)
    Indications
    Insulin replacement
  40. Glargine (Lantus) Zinc Suspt. Ultralente - Humulin U
    Indications
    Insulin replacement

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