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Osmotic Diuretics - Names
Mannitol Glucose, Osmatol
Acetazloamide - Diamox
MOST COMMONG - Loope Diuretics
Furosemide - Lasix
Thiazide and Related Diuretics
Hydrochlorthiazide - Zaroxolyn (metolazone) HCTZ
Potassium Sparing Diuretics
- ACTION: Proximal tubule nonabsorbable, produces an osmotic effect, pulls water into the blood vessels and nephrons from the surrounding tissue.
- INDICATIONS:Reduces risk of acute renal failure in low flow dehydration hypotension hypovolemic shock, prevent renal failure druing long surgery reduces intracranial pressure before and after neurosurgery reduces intra occular purssure before opthalmic surgery promotes urniary excretion of toxic substances (drug overdose)
- SIDE EFFECTS: HA, N/V Pulmonary Edema
- Contraindications: CHF, Anuria, Pulmonary edema, severe dehydrations <12yrs old/ Pg.
Acetazloamide - Diamox
- ACTIONS: Prevents the reabsorption of Bicarb ions from proximal tubule which increases tubular osmotic pressure resulting in osmotic diuresis
- INDICATIONS: Open angle glaucoma, management of seizures, drug overdose, altitiude sickness
- SIDE EFFECTS: HA, Nervousness, ataxia, alopecia, depression, tremors, anorexia, increase serum glucose, potassium wasting
- Contraindications: allergy to sulfonamides, renal or resp acidosis, hepatic impoarment
- ACTIONS: reduces after load, reduces preload, decreasesd fluid volume, causes reduced BP, Pulmonary vascular resistance, rediced systemic vascular resistance, Blocks the chloride pump in ascending loop where 30% of sodium is usually reabsorbed Loss of Na, K, Mg, H2O lost
- INDICATIONS: Pulmonary edema, acutre renal failure,
- severe edema due to CHF, renal or liver dx, management of acites control of HTN promotes Ca++ excretion.
- SIDE EFFECTS: Hypokalemia, orthostatic hypotension, anorexia, abdominal discomfort, weakness, muscle
- cramps (low K+) N/V HA, Rash, photosensitivity, alkalosis, blood dyscrasias, hyperglycemia, hyperuircemia, hypo-calcemia, mg. hearning loss, electrolyte imbalance
- Contraindications: Anureia, electrolyte depletions and hypotension, dehydrations, pg use w/caution, infants, monitor diabetics hyperglyycemia
Lassix Onset & Duration
Mannitol Onset & Duration
Acetazloamide - Diamox Onset & Duration
- Onset - Oral 30-60Min
- Onset - IV - 5 min
- Duration - Oral
- Duration - IV - 2Hrs.
- Onset - 30-60
- Duration - 6-8 hrs.
- Acetazloamide - Diamox
- Onset - Rapdi
- Duraiton - 2-4 days