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Any disease that narrows the coronary arteries
Coronary Artery Disease /CAD
General term for all types of arteriole changes
Thickening, loss of elasticity & calcification of arteriole walls
Leads to narrow lumens, ishemia, & necrosis
Form of arteriosclerosis
Presence of artheromes
Thickening and hardening of the arteries due to lipid, fibrin, debris, and thrombus hardening
What are the general effects of Artheroclerosis?
- Decrease perfusion of organs
- Increase platelet adhesion
- promotes the development of aneurysm
How does an atheroma begin to form?
endothelial injury to an artery, which rasises C-reactive proteins
What is the earliest atheroma lesion?
What do fatty streaks consist of?
- lipid filled smooth muscle
Thin yellow discolorations of artery tunica intima that progressively enlarge over time
What are the characteristic lesion of advancing athersclerosis?
blood levels high in LDL and cholesterol
Where do thrombuses usually form
biofurcations of large arteries(aorta, coronary, carotid, illiac)
What are the consuqences of arthersclerosis?
- Myocardial Ischemia
- Myocardial Infarction(Heart Attack)
Intermittent periods of Ischemia
Cardiac muscles are alive, but unable to function normally
Death of Cardiac muscle
Occurs when Ischemia is over 20 minutes
What are the risk factors for CAD?
- Sedentary Lifestyle
Localized contraction of arteriolar smooth muscle