Card Set Information
Metabolic X syndrome includes which 3 components
Zucker Fatty Rat is a model for what disease
Genetic Obesity (leptin receptor mutation)
SHROB is a model for what disease?
Genetic obesity, metabolic disease
Kol is the lean littermate
DIO is a model for what disease
Nutritional obesity- normal leptin
metabolic syndrome X
Osborne-Mendel is a study for what disease?
BBDP is a model for what disease?
BBDP/Wor for Type I diabetes
ZDF rat is a model for what disease
ZDF-Type 2 Diabetes Mellitus
What is the gender difference with ZDF rats?
Male ZDF develop diabetes in a different diet, females need more fat and lower protein
Cohen Diabetic Rat is a model for what disease?
Type II diabetes
Goto-Kakizaki (GK) rat is a model for what disease
Type II diabetes, ESRD
Otsuka Long-Evans Tokushima Fatty Rat (OLETF) is a model for which disease?
Type II diabetes
Wistar Fatty Rat is a model for which disease?
Type II diabetes
Injection of STZ in the neonate causes what?
Type II diabetes (n-STZ)
Injection of STZ in the adult rat causes what?
Type I diabetes
SHR is a model for what disease?
Genetically Hypertensive Rat (GH) are a model for what disease?
Fawn Hooded Hypersensitive rat (FHH) is a model for what disease?
Lyon Hypertensive rat is a model for what disease?
Spontaneous hypertension without hyperinsulinemia
Sabra Hypertension Prone (SBH) is a model for what disease
Spontaneous hypertension, salt sensitive and testeosterone dependent
Milan Hypertensive (MHS) is model for what disease?
Dahl Salt sensitive (SS/Jr) is a model for what disease
Salt sensitive hypertension
Young SS/Jr is a model for what disease
Genetically Epilepsy Prone Rats (GEPR/3 and GEPR/9) are a model for what disease?
generalized genetic epilepsy
WAG/Rij is a model for what disease
Genetic petit mal or absence epilepsy
Genetic absence epilepsy rat from Strasboug (GAERS) is a model for what disease?
Genetic absensence epilepsy
When giving a DA rat complete Freunds adjuvant +MBP, what happens?
Experimental Autoimmune Encephalomyelitis Multiple Sclerosis
When giving a LEW rat incomplete Freunds adjuvant +MBP what happens?
What are the 3 compounds that can be given to a rat to induce Parkinsons
rotenone, MPTP, and 6-hydroxy dopamine
ZDF and BB/Wor have been studied for what besides diabetes?
Lobound Wistar (LW) rat is a model for what disease
Noble rat is a model for what disease?
COP and WF are models for what disease and how do they differ?
COP is a negative model, dominant resistant gene to mammary carcinogenesis
WF- mammary cancer suceptible
ZSF1 rats are a model for what disease?
End Stage renal disease
Han:SPRD Cy/Cy is a model for what disease?
Autosomal Dominant Polycystic Kidney Disease
Brattleboro rats are a model to what disease?
Diabetes Insipidis, neurogenic
M520/DI is a model for what disese
SHPSP is mode for waht disease
cerebrovascular lesions, proteinuria
SHHF is a model for what disease
Spontaneous Hypertensive Heart Failure Rat is a model for type 2 diabetes, CHF, and Obesity
JCR:LA-cp is a model for what disease?
cp corpulent, cardiovascular disease
Name 5 compounds that can be injected to create a model for autoimmune rheumatoid arthritis
Type II collagen
complete Freunds adjuvant
Incomplete Freunds adjuvant
Streptococcol wall (LEW)
DA is very susceptible, BB (DR)