Paraneoplastic effects of tumors

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Author:
manjinder
ID:
151758
Filename:
Paraneoplastic effects of tumors
Updated:
2012-05-02 18:34:13
Tags:
Pathology
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Description:
Pathology
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  1. Small cell lung carcinoma
    • Effects: cushing's syndrome, SIADH, Lambert-Eaton Syndrome (muscle weakness)
    • Hormone/agent secreted: ACTH or like peptide, ADH, Antibodies against presynaptic Ca2+ channels at neuromuscular junction
  2. Intracranial neoplasms
    • Effect: SIADH
    • Hormone: ADH
  3. Squamous cell lung carcinoma
    • Effect: hypercalcemia
    • Hormone/agent: PTH-related pepetide, TGF-b, TNF, IL-1
  4. Breast carcinoma
    • Effect: hypercalcemia
    • Hormone/agent: PTH-related pepetide, TGF-b, TNF, IL-1
  5. Renal cell carcinoma
    • Effect: hypercalcemia, polycythemia
    • Hormone/agent: PTH-related pepetide, TGF-b, TNF, IL-1, erythropoietin
  6. Hemangioblastoma, hepatocellular carcinoma, pheochromocytoma
    • Effect: polycythemia
    • hormone/agent: erythropoietin
  7. Thymomoa
    • Effect: Lambert-Eaton syndrome (muscle weakness)
    • Hormone/agent: Antibodies against presynaptic Ca2+ channels at neuromuscular junction
  8. Leukemias and lymphomas
    • Effect: gout, urate nephropathy
    • Hormone/agent: hyperuricemia due to excess nucleic acid turnover

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