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The study of the reactions of a host when foreign substances are introduced into the body
Immunology
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Foreign substances that induce such an immune response
antigens
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The condition of being resistant to infections.
immunity
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Discovery of small pox vaccine
Edward Jenner
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Deliberately exposing an individual to material from smallpox lesions to reduce effects of the disease
Variolation
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Procedure of injecting immunogenic material into the body to induce immunity
Vaccination
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Live organisms that have been changed by heat, age, or chemical means
attenuated vaccine
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Protection that is always present
Innate immunity
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Protection that arises by an immune response
Adaptive immunity
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Substances, usually proteins, present in any bodily fluid
Humoral
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Innate and adaptive further divided into:
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Serum factors in the blood formed in response to exposure to foreign substances
Antibodies
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The study of the noncellular components in the blood
Serology
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Process by which particulate antigens, such as cells, aggregate to form larger complexes when a specific antibody is present
Agglutination
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The combination of a soluble antigen with a soluble antibody to produce visible insoluble complexes
Precipitation
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Functions in early stages of host defense in response to an antigen
Natural response
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When antigen causes a disease, it is a?
pathogen
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Cells engulf and degrade antigen
Phagocytosis
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What are the two populations of phagocytes?
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Soluble proteins that regulate immune responses
Cytokines
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Defend against virally infected cells and some tumor cells.
Natural Killer Cells
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Main host defense mechanism activated in response to parasitic infections, particularly helminths.
Eosinophils
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When basophils degranulate in excessive amounts, an enormous hypersensitivity results
anaphylaxis
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They are the most potent phagoctyic cell in the tissues
Dendritic Cells
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Most widely used indicator of acute inflammation
Latex agglutination test for elevated levels in the serum
C-reactive protein
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A series of serum proteins that are normally present
Overall function: Mediation of inflammation
Complement
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Mechanisms activated in tissue damage referred to a:
Inflammatory Response
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Designed for antigens and antibodies very small in size or in very low concentrations
Indicator-Labeled Immunoassays
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Indicator-Labeled Immunoassays:
The presence of antigens or antibodies is determined _____________ by using a labeled reagent.
Indirectly
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Make it possible to quantitate antigen or antibody
Labels
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Labels:
The substance to be measured is known as an
Analyte
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Indicator labels for immunoassays fall into four broad categories:
- Radioactive isotopes
- Fluorochromes
- Enzymes
- Chemiluminescent tags
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The key cell involved in the immune response
Lymphocyte
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Two primary lymphoid organs
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Effector cells serving a regulatory role
T lymphocytes
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Produce antibody
B lymphocytes
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Large, granular, & plays a role in both the innate &
adaptive immune response
NK Cell
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