Describe four major behavioral abnormalities of autism (social, communication, repetitive and inflexibility) and tests in mice that can be used to examine those
• Social withdrawal (cortex, hippocampus, amygdala)– Can be tested by social interactions, social recognition, ultrasonic vocalizations (pup retrieval), juvenile play
• Repetitive behaviors (cerebellum)
• Unable to read social mind (mirror neurons in the cortex)– Tested by empathy?
• Inflexibility (hippocampus, cortex)– Tested by the reversal of the platform in the Morris water maze