Reteplase

Card Set Information

Author:
Kgren
ID:
153302
Filename:
Reteplase
Updated:
2012-05-10 12:44:21
Tags:
Paramedic Drugs
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Description:
Reteplase
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  1. Class
    Fibrinolytic
  2. Description
    DNA recombinant human tissue type plasminogen activator that acts as a catalyst in the breakdown of plasminogen to plasmin
  3. Mechanism of Action
    • Increases plasmin by increasing conversion of plasminogen to plasmin.
    • Breaks down clots
  4. Onset of Action
    • Onset: < 5min
    • Peak: Varies
    • Duration: Varies
    • Half-life: 13-16min
  5. Indications
    Acute Coronary Syndrome
  6. Contraindications
    • Active Bleeding
    • Ulcers/Bleeding disorder
    • GI bleed
    • Suspected Aortic disection
    • Traumatic/Prolonged CPR
    • HTN
    • Head trauma
    • Intercranial abnormalities
    • Recent stroke
    • Pregnancy
    • Cancer
    • Liver dysfunction
    • Kidney failure
    • Recent surgery
  7. Precautions
    Have available: Antidysrhythmics, Emergency resuscitation medications and equipment
  8. Side Effects
    • Bleeding
    • Anaphylaxis
    • Allergic reactions
    • Fever
    • Nausea
    • Vomiting
  9. Adult Dose
    • 10 units over 2 min
    • Repeat in 30 min
  10. Pedi Dose
    Not indicated
  11. Max Dose
    20 units
  12. Route of Administration
    IV/IO
  13. How Supplied
    Vials

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