Polypeptide hormone extracted from the posterior pituitaries of animals. It possesses pressor and antidiuretic hormone properties. Conclusive evidence supporting the use of vasopressin in cardiac arrest is lacking
Mechanism of Action
Vasopressin, in higher doses, acts as a non-alpha-adrenergic vasoconstrictor through direct stimulation of smooth muscle receptors. It can be used as an alternative to epi during cardiac arrest
Onset of Action
Duration: 30-60 min
Half-life: 10-20 min
Used to increase peripheral vascular resistance during CPR as an alternative to or after epi has been used.
1 Dose may replace the first or second dose of epi in cardiac arrest