Pulmonary Edema: AAAA promotes the renal excretion of water, sodium, chloride, magnesium, hydrogen, and calcium; it depletes potassium. Furosemide also has peripheral and renal vasodilating effects that can lower blood pressure. The client’s fluid and electrolyte status must be carefully assessed before and after furosemide administration, including auscultation of breath sounds for rales, strict surveillance of intake and output, and review of laboratory data when available. An indwelling urinary catheter might be necessary. Electrolyte and fluid replacement may be required during furosemide therapy to prevent physiologic consequences. The nurse must also exercise caution in administering the drug to clients with sulfonamide sensitivity, because furosemide is a sulfonamide derivative and can produce an allergic reaction.