S3M1 innate and comp

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sweetlu
ID:
153460
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S3M1 innate and comp
Updated:
2012-08-09 09:06:54
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S3M1innate comp
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S3M1 innate and comp
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  1. IL-8
    - neutrophil chemoattractant
  2. TNF-alpha
    • - induce macrophage production of proinflammatory molecules IL-1 and PG-E2
    • - activate NK cells
    • - chemotaxis
  3. IL-2
    - induce proliferation of lymphocytes and NK cells
  4. INF- alpha, beta and gamma
    • - inhibit viral replication
    • - activate NK cells
  5. type 1 PRR
    • - initiate lectin p/w of complement
    • - induced by IL-6 acting on liver
    • - includes mannin binding lectin and binds microbial CHOs
    • - secreted molecules produced in liver that circulate in blood and lymph
    • - released in an acute phase response
  6. type 2 PRR
    • - phagocytosis and delivery to lysosomes and MHC presentation
    • - high affinity for CHO with many mannose
    • -
  7. type 3 PRR
    • - TLR's
    • - activation of NF-kB signalling p/w (a TF)
    • - cytokine gene expression (prod and release)
    • - macrophages, dendritic cells and epithelial cells
  8. TLR's and what they bind
    • - TLR-2===> peptidoglycan of G+
    • - TLR-3===> dsRNA
    • - TLR-4===> LPS of G-
    • - TLR-5===> flagellin
    • - TLR-7===> ssRNA
    • - TLR-9===> unmethylated CpG DNA (bacteria and virus)
  9. C1 INH
    • - C1 esterase inhibitor
    • - inactivates C1r and C1s
    • - classical p/w regulation
  10. Factor I
    • - inactivates C4b in classical p/w
    • - inactivates C3b in alternative p/w
  11. C4b2b
    • - C3 convertase of classical and lectin p/w
    • - activation unit
    • - requires Mg
  12. C4b2b3b
    - C5 convertase of classical and lectin p/w
  13. C1q,r,s
    - recognition unit of classical p/w
  14. Properdin
    • - promoter of alternative p/w
    • - stabalizes C3bBb
  15. Factor H
    - decays C3bBb of alternative p/w
  16. C3bBb
    • - C3 convertase of alternative p/w
    • - activation unit
  17. C3bBbC3b
    - C5 convertase of alternative p/w
  18. CD59
    • - MAC inhibitor
    • - "homologous restriction factor"
    • - protects host cells from complement
  19. CR1
    • - found on RBC, B cells, granulocytes and monocytes and m0
    • - RBC transport of immune complexes
    • - promotes C3b and C4b decay
    • - stimulates phagocytosis
    • - very common
  20. CR2
    • - part of B cell co-receptor
    • - CD21
  21. CR3
    • - monocytes, m0 and granuloctes
    • - stimulates phagocytosis
  22. C5a>C3a
    • - act as anaphylaxatoxins (C4a also_
    • - they also promotes chemotaxis of n0 and monocytes
    • - enhance adherance of phagocytes to vascular epithelium
  23. tetrazolium dye test
    - tests funcionality of n0
  24. Recurring infection types seen in primary immunodeficiencies
    • B cell/Ig= bacterial pneumonia
    • Complement= pyogenic infection, disseminated Neisseria
    • Phagocytes= uncommon systemic bacterial infections and abscesses
    • Tcells= opportunistic infections (fungi, viruses, protozoa)

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