S3M1 immuno

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sweetlu
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153679
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S3M1 immuno
Updated:
2012-05-26 18:00:36
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S3M1 immuno
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S3M1 immuno
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  1. CD19
    - signalling chain of BCR complex
  2. Ig alpha and IG beta
    - complex with BCR and mediate IC signaling
  3. CD21
    • - aka complement receptor 2
    • - recognizes C3d fragments
  4. CD3
    • - aids TCR signal transduction
    • (similar to Ig alpha and beta on a BCR)
    • - deficiency leads to NO T CELLS, becuase they can not be properly made without CD3
  5. IL-12
    • - CD4 Tcell==> Th1
    • - released by APC in response to EC pathogens and intravesicular pathogens that persist in the M0
    • - INF- gamma also released from APC
  6. IL-4
    • - CD4 T cell==> Th2
    • - B cell==> IgE
    • - Released by APC in response to helminths and parasites
  7. IL-2
    - stimulates T cell clonal expansion
  8. CD2
    - expressed on commited double- negative T cell progenitor
  9. CD34
    - expressed on uncommited progenitor cell
  10. IL-23
    • - CD4 T cell==> Th17
    • - released by APC in response to EC bacteria
    • - will enhance neutrophil response
  11. IL-6
    • - CD4 T cell==> Th17
    • - released by APC with TGF-beta in response to EC bacteria
    • - will lead to enhancement of neutrophil response
  12. T regs
    • - induced by TGF-Beta
    • - release TGF-beta and IL-10
  13. Th17
    • - induced by IL-6 and TGF- beta
    • - release IL-6 and IL-17
    • - enhance neutrophil response
  14. Th1
    • - induced by IL-12 and INF-gamma
    • - release IL-2 and INF-gamma
    • - act on m0 with persistant intravesicular pathogen and EC pathogens
  15. Th2
    • - induced by IL-4
    • - release IL-4 and IL-5
    • - act on helminth infections
  16. cytokines that promoote eosinophil production and activation
    - IL-3, IL-5, GM-CSF
  17. IFN-gamma
    - activates macrophages
  18. cytokines of T4HS (DTH)
    • - chemokines- m0 recruitment
    • - IFN-g- activate m0 and increase release of inflam mediator
    • - TNF-a and LT- local tissue destruction, increased adhesion molecule expression on local blood vessels
    • - IL-3/GM-CSF- monocyte production
  19. Blood agar
    - pattern of hemolysis can aid ID
  20. chocolate agar
    • - prelysed RBC's
    • - for organisms with difficult nutritional req
    • - Haemophilus and Neisseria
  21. Mannitol-salt agar
    • - high salt inhibits most organisms
    • - S. aureus can stand high salt
    • - S. aureus fermentation of mannitol=> indicator turns yellow
  22. MacConkey agar
    • - selective for G- organisms
    • - Lactose is sole CHO
    • - pink/red colonies= lactase +
    • - clear colonies= lactase -
  23. Eosin Methylene Blue (EMB) agar
    • - selective for G-
    • - lactose is sole CHO
    • - lactose fermenters= blue/black colonies
    • - non lactose fermenters= clear colonies
    • - green metallic colonies= E. cole
  24. Bile esculin
    • - bile salts inhibit G+ growth
    • - selective for Streptococci and Enterococcus
  25. Hektoen enteric agar
    • - isolation of enteric pathogens
    • - fermenters= yellow/pink
    • - nonfermenters= green or transparent
    • - H2S producers= black
  26. Cetramide agar
    - Selective and differential for Pseudomonas aeruginosa
  27. Tellurite agar
    - selective and differential for Corynebacterium diphtheriae
  28. Chromogenic agar
    • -selective, differential and quickly visuallized
    • - Listeria monocytogenes and S. aureus
    • - phenotypes such as MRSA or MSSA
  29. Coagulase tests
    - agglutination= detect bound coagulase (clumping factor)

    - tube= detect free coagulase
  30. Thioglycolate media
    • - has a O2 gradient
    • - used to test O2 tolerance
  31. minimun specimen labling
    • patient name
    • ID number
    • Specimen source
    • Ordering physician
    • Date/hour collected
  32. Serology test
    • for organisms difficut or dangerous to cultivate
    • track pt course of illness
    • determination of immume status
  33. Nucleic acid test
    • very sensitive and specific
    • useful for viruses
    • can screen for >1 pathogen at a time
    • tracking viral load to manage therapy
  34. Antigen detection
    • - antigen must be produced in high enough amounts to be detected
    • - low sensitivity and low sensitivity (other confirmations are necessary)
    • - very rapid assay (ie antigen detection for cause of meningitis)

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