FA Bacterial toxins

Card Set Information

Author:
USUHS14
ID:
154038
Filename:
FA Bacterial toxins
Updated:
2012-05-15 19:41:05
Tags:
First aid bacteria extotoxins micro
Folders:

Description:
Name the mechanism for the given toxin
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  1. Diphtheria toxin
    Inactivates elongation factor 2
  2. Exotoxin A (Pseudomonas)
    Inactivates elongation factor 2
  3. Shiga toxin
    Inactivates 60S ribosome by cleaving rRNA
  4. Shiga-like toxin
    Inactivates 60S ribosome by cleaving rRNA
  5. Heat-labile toxin (LT)
    Over activates adenylate cyclase -> inc Cl- secretion in gut and H2O efflux
  6. Heat-stable toxin (ST)
    Over activates guanylate cyclase -> dec reabsorption of NaCl and H2O in gut
  7. Edema factor
    Mimics the adenylate cyclase enzyme (inc cAMP)
  8. Cholera toxin
    Over activates adenylate cyclase by permanently activating Gs -> inc Cl- secretion in gut and H2O efflux
  9. Pertussis toxin
    Over activates adenylate cyclase by disabling Gi, impairing phagocytosis to permit survival of microbe
  10. Tetanospasmin
    Cleaves SNARE protein required for neurotransmitter release (on alpha-motor neuron)
  11. Botulinum toxin
    Cleaves SNARE protein required for neurotransmitter release (on inhibitory neuron)
  12. Alpha toxin
    Phospholipase that degrades tissue, cell membranes
  13. Streptolysin O
    Protein that degrades cell membrane (specifically RBC)
  14. Exotoxin A (Strep)
    Superantigen - brings MHC II and TCR in proximity to cause overwhelming release of IFN-gamma and IL-2 -> shock

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