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Which nonpharmacologic alternative have shown to be efficacious in the treatment of nausea?
Which vitamin does green tea contain and must therefore be cautious in patient under warfarin therapy?
What is a significant side effect of licorice?
Hypokalemia because licorice is a mineralocorticoid analog.
What is the marketed indication for saw palmetto?
For BPH. It does not interfere with PSA test.
The American Heart Association recommends AGAINST the use of which nonpharmacologic alternative for treatment and prevention of hyperlipidemia, or for breast, endometrial, or prostate cancer?
What side effects have been associated with using Yohimbe?
There have been reports of seizures and deaths since it causes CNS stimulation and HTN.
Why is IV codeine contraindicated in children?
IV use in children is contraindicated since it can promote excessive histamine release and cardiovascular problems.
What is the approved use foor oral transmucosal delivery of Fentanyl?
For breakthrough cancer pain
What cautions must be taken with using Meperidine?
1. May cause seizures, particularly in patients with renal problems, the elderly, or those taking MAO inhibitors, or in anyone taking a high dose.
2. May cause serotonin syndrome when used concurrently with SSRIs, SNRIs, or MAOIs.
What side effect is seen with high doses of methadone?
Torsade de Pointe
What kind of drug interactions does Methadone have the potential of having or making?
P450 Inducers significantly reduce serum methadone levels (and methadone itself is a P450 inducer)
What are the contraindications associated with Propoxyphene?
Propoxyphene is an opioid used for mild to moderate pain.
-->It is contraindicated with renal failure and the elderly because of a significantly increased risk for seizure, CNS disturbance, and QRS prolongation.
Which nonpharmacologic alternative is marketed for use to treat postmenopausal vasomotor symptoms and for the pain of oral aphthous ulcers?
What is the specific indication for oral Buprenorphine?
Oral buprenorphine is called Subutex and is used for treatment of opioid dependence.
What are the ADRs associated with Pentazocine?
Pentazocine is an opioid agonist-antagonist with ADRs including:
What is Suboxone?
Suboxone is the tradename for the combination of Subutex (buprenorphine) and Naloxone for treatement of opioid dependence.
Which drugs belong to the class, Selective Serotonin Reuptake Inhibitors?
Which medications are classified as Tricyclic Amines?
1. Amitriptyline- affects serotonin
3. Clomipramine - affects serotonin
5. Imipramine - affects both serotonin and norepinephrine
Patients on MAO inhibitors should avoid foods that contain what?
--> No ingestion of wine, beer, cheese, liver, grapes, avocados, sauerkraut, processed meats, chocolate, soy products
What is Bupropion?
It is a dopamine reuptake inhibitor and a nicotinic antagonist.
--> Contraindicated in seizure disorder, eating disorders.
--> ADRs: Seizures
What is Mirtazapine?
An antidepressant that works by stimulating norepinephrine and serotonin release, and inhibits serotonin reuptake.
--> ADRs: drowsiness, increased appetite/weight gain, agranulocytosis
What should you monitor for in patients placed on Serotonin-Norepinephrine Reuptake Inhibitors?
Monitor for the emergence of anxiety, panic attacks, insomnia, and irritability.
1. Desvenlafaxine - therapeutic dose can be started on day one of therapy, without starting an initial ramp-up dose first
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