Inhibits conversion of AT1 to AT2 which is a potent vasoconstrictor
Inhibits bradykinin breakdown
Increasesnplasma renin activity due to a decrease in AT2 and therefore results in decreased aldosterone and therefore a decrease in sodium and water retention
Moa for hydrochlorothiazide?
Increased urinary excretion of sodium and water by inhibiting sodium reabsorption in the early distal tubles
Decreases plasma and extra cellular volume therefore decreases cardiac output and peripheral resistance
Metabolite of allopurinol? How does that work?
Inhibits Xanthine Oxidase and therefore inhibits Uris acid synthesis
The metabolite oxypurinol also inhibits xanthine oxidase
Moa of colchicine?
Inhibits neutrophil migration, adhesion and Phagocytosis to the inflamed area. Has no effects on the production of Uric acid or the excretion
Moa of ssri's
Selectively inhibit the presynaptic reuptake of serotonin
Moa of steroid creams
Anti-inflammatory, immunosuppressive and antimitotic activity against cutaneous fibroblasts and epidermal cells. They are also vasoconstrictive.
Moa of pimecrolimus
inhibits calcineurin thus blocking t cell proliferation And preventing release of inflammatory cytokines
Moa of ppis
What happens when ppis are stopped?
Irreversibly inactivate the hydrogen/potassium ATPase enzyme system (proton pump), suppressing both stimulated and basal acid secretion. When PPIs are stopped, acid secretion is restored by synthesis of new hydrogen/potassium ATPase.