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2012-05-18 07:38:27

Modes of action of drug classesx
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  1. What is the moa for acei?
    • Inhibits conversion of AT1 to AT2 which is a potent vasoconstrictor
    • Inhibits bradykinin breakdown
    • Increasesnplasma renin activity due to a decrease in AT2 and therefore results in decreased aldosterone and therefore a decrease in sodium and water retention
  2. Moa for hydrochlorothiazide?
    Increased urinary excretion of sodium and water by inhibiting sodium reabsorption in the early distal tubles

    Decreases plasma and extra cellular volume therefore decreases cardiac output and peripheral resistance
  3. Allopurinol moa?
    Metabolite of allopurinol? How does that work?
    • Inhibits Xanthine Oxidase and therefore inhibits Uris acid synthesis
    • The metabolite oxypurinol also inhibits xanthine oxidase
  4. Moa of colchicine?
    Inhibits neutrophil migration, adhesion and Phagocytosis to the inflamed area. Has no effects on the production of Uric acid or the excretion
  5. Moa of ssri's
    Selectively inhibit the presynaptic reuptake of serotonin
  6. Moa of steroid creams

    • Anti-inflammatory, immunosuppressive and antimitotic activity against cutaneous fibroblasts and epidermal cells. They are also vasoconstrictive.

  7. Moa of pimecrolimus
  8. Anti inflammatory
    inhibits calcineurin thus blocking t cell proliferation And preventing release of inflammatory cytokines
  9. Moa of ppis
    What happens when ppis are stopped?

    • Irreversibly inactivate the hydrogen/potassium ATPase enzyme system (proton pump), suppressing both stimulated and basal acid secretion. When PPIs are stopped, acid secretion is restored by synthesis of new hydrogen/potassium ATPase.