S3M1 cytokines

Card Set Information

Author:
sweetlu
ID:
154654
Filename:
S3M1 cytokines
Updated:
2012-06-02 19:21:45
Tags:
S3M1 cytokines
Folders:

Description:
S3M1 cytokines
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user sweetlu on FreezingBlue Flashcards. What would you like to do?


  1. IL-1
    • - major inflammatory cytokine
    • - inflammation (vasculature), fever(HT), induction of APP's(liver)
    • - secreted by m,m0, endothelial and epithelial cells
  2. TNF-a
    • - major inflammatory cytokine
    • - inflammation (vasculature), induction of APP's(liver), n0 activation, cachexia, induction of death in many cell types
    • - m0 produced
  3. IL-12
    • - Th1 response
    • - NK response
  4. IL-6
    • APP's (liver)
    • Th17 differentiation
    • promotes proliferation and terminanal differentiation of B cells
    • similar properties to IL-1
  5. INF-a
    - inhibits viral replication and supresses cell proliferation
  6. INF-b
    - antiviral activity, cytostatic for tumors, stimulation of B cells and pyretic
  7. INF-g
    • - tx of CGD
    • - messenger b/t Th cells and phagocytes
  8. IL-2
    • -promotes growth of T cells
    • - act on B cells, NK cells and LAK cells
  9. IL-3
    • - aka CSF
    • - stimulates hematopoesis of multiple lineages
    • - proinflammatory and mast cell stim.
  10. IL-4
    • - B cell prolifeation and differentiation
    • - isotype switch IgG1 and IgE
    • - proliferation of Th2
    • - inhibition of Th17
    • - upreg of MHC2 on m0
    • - mast cell growth
  11. IL-5
    • - e0 production
    • - IgA production
  12. Il-7
    secreted by BM stromal cells and thymocytes
  13. IL-8
    • (CXCL8)
    • chemokine for n0, T cells, b0
    • mast cell degranulation
    • promotes angiogenesis
  14. IL-9
    • stimulate cytotoxicity of CTL's and NK cells
    • stimulates other IL release
    • may be involved in asthma pathogenesis
  15. IL-10
    • inhibition of proinflammatory cytokine from m and m0 (inflammation stop signal)
    • promotes B cell proliferation
  16. IL-11
    • induce haemopoeisis
    • production of APPs by hepatocytes
  17. IL-13
    • promotes IgE production
    • has anti-inflammatory properties
  18. IL-14
    • BCGF
    • - hyperproduction promotes development of B-cell non-Hodgkins lymphoma
  19. IFN-gamma
    • major macrophage- activating cytokine
    • secreted by NK cells and activated T cells
  20. IL-17
    recruitment of neutrophils and monocytes

What would you like to do?

Home > Flashcards > Print Preview