Is key component of the microsomal enzyme system because it metabolizes drugs within cells.
Within family is: CYP1, CYP2, CYP3, et al
Each enzyme is termed an isoform, since each is derived from a different gene...SO…. Genetic alterations in drug metabolism correlates to these enzymes
- Inhibitors: (Inhibits CYP450, and therefore increases drug effect)
- Decreases metabolism of substrates which leads to increased drug effect unless drug is a prodrug
Inductors: Increases drug metabolism of substrates which leads to decreased drug effect unless drug is a prodrug