diabeters

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Author:
kmegk22
ID:
154929
Filename:
diabeters
Updated:
2012-05-20 18:49:08
Tags:
diabetes
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Description:
diabets
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  1. SU- MOA
    pumps insulin out of pancreas
  2. SU
    • Glyburide (diabeta, micronase)- active
    • metabolites that are renally cleared- ↑ risk of hypoglycemia in renal insuff

    • Glipizide
    • (glucotrol)

    • Glimepiride
    • (amaryl)

    • SE: HYPOGLYCEMIA,
    • rash, weight gain (any drug that promotes insulin promote wt gain)
  3. biguanide MOA
    • Inhibits glucose
    • release from the liver, enhances muscle peripheral glucose intake
  4. metformin
    • SE: GI (transient
    • diarrhea- must titrate), to a goal of 1500mg/day,

    • Crcl- 1.4/1.5- you
    • hold onto more drug→ lactic acidosis- IT IS NOT NEPHROTOXIC

    • Advantages: wt
    • loss/wt neutral, improve cholesterol levels
  5. alpha glucoside inhib MOA
    ⇓ absorption of sugars in brush boarder of intestine
  6. Acarbose
    Miglitold
    • Used at meal time
    • Decreasing postprandial glucose levels

    SE: flatulence, abdominal bloating
  7. TZD MOA
    • MOA: ↓ insulin
    • resistance at the PPAR gamma receptor by improving uptake and muscles
  8. TZD
    Rosiglitazones (avandia) - do not use in heart failure

    Pioglitaone (actos)

    SE: wt gain (edema), ↑ LDL, monitor liver associated enzymes
  9. meglitinides
    Repaglinide (prandin)

    Nateglinide (starlix)

    Basically short acting SU, increase insulin output from pancreas-- do not take if you don’teat--

    take 15-30 mins before meals
  10. meglitinide MOA
    stimulate insulin secretion from beta cells
  11. GLP 1 agonists MOA
    MOA: decrease glucose by decreasing glucagon
  12. GLP 1
    Liraglutide (victoza)- 1.2-1.8mg/day

    • Exanatide (byetta) 5-10mcg 2 x daily
    • SE: pancreatitis, nauses (titrate)

    take 60 mins within meal
  13. DDPIV inhib MOA
    prevents breakdown of GLP
  14. DDP IV
    • Saxigliptin
    • (onglyza) 2.5-5mg daily

    • Sitaglyptin
    • (januvia) 100mg daily

    se: nasopharyngitis, upper resp tract, peripheral edema, rash,
  15. symlin (premlintide)
    take immediately before a meal
  16. rapid insulins
    • lispro, aspart, glulisine
    • humulog, novolog, apidra
  17. when to take rapid
    with meals
  18. regular insulin
    • humulin r
    • novolin r

    take 30 mins before meal
  19. intermediate/ NPH
    • humulin N .. L
    • Novolin N... L
  20. freq of NPH
    BID
  21. basal
    • determir (levemir)
    • gargine (lantus)

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