osteoporosis

Card Set Information

Author:
kmegk22
ID:
154941
Filename:
osteoporosis
Updated:
2012-05-20 19:35:31
Tags:
osteo
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Description:
osteo
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  1. osteopenia
    T score -1 to -2.5
  2. osteoporisis
    t score below -2.5
  3. osteoblast
    bone formation
  4. osteoclast
    break down bonw
  5. calcium citrate
    • with or without food
    • can use PPIs
  6. calcium carbonate
    • acid dependent
    • take with food/ juice
  7. vitamin D
    • 600 IU daily
    • D2: renal dx, short term
  8. bisphosphonates- name em
    • alendronate- fosamax- 70 weekly
    • risedronate- actonel - 35 weekly
    • ibandronate- boniva- 150 monthly
    • zoledronic acid- reclast- 5mg yearly
  9. bisphos SE
    • back pain, arthralgia, dyspepsia, esophagitis, jaw necrosis
    • STOP AFTER 5 YEARS- atypical fracture
  10. estrogen receptor modulator MOA
    dec bone resorption

    evista
  11. Raloxifen (evista)
    • compelling: risk of BA, inc LDL
    • SE: hot flash, HTN, mood, amenorrha,
    • CI: DVT, MI
  12. calcitonin nasal spray
    • MOA: inhibits osteoclasts
    • fortical- one spray in alternate nostrils
    • SE: rhinitis, dizziness, flu
  13. teripoaratide- forteo
    • MOA: stimulate new bone formation and dec osteoclast- HIGH RISK
    • se: dizzy, inc HR, inj site, HA, arthralgia, inc ca post dose, inc uric acid
    • CI- bone metastatsis
  14. monoclonal ab
    MOA: binds to RANKL to prevent osteoclas formation, dec resportion and inc bone mass -HIGH RISK

    • denosumab- prolia, xgena
    • SE: hypocalcemia, anemia, jaw necrosis

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