Chapter 20, Cirrhosis

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  1. chronic irreversible damage to liver causing fibrosis and nodules
    cirrhosis
  2. Explain the patho of cirrhosis
    • fat accumulates
    • nodules appear
    • lobular organization lost
    • hepatocytes non-functional
    • bile and toxins back up inro blood
  3. what is the etiology of cirrhosis
    • alcoholic liver disease(portal Cirrhosis)
    • billiary cirrhosis
    • postnecrotic cirrhosis
    • metabolic cirrhosis
    • idiopathic
  4. which cirrhosis is the most common
    portal cirrhosis(alcoholic liver disease)
  5. what are the stages of portal cirrhosis
    • fatty liver
    • alcoholic hepatitis
    • end-stage cirrhosis
  6. what occurs during the first stage of portal cirrhosis
    • hepatomegaly
    • asymptomatic
    • reversible
  7. what occurs during the alcoholic hepatitis stage of portal cirrhosis
    • necrosis
    • fibrosis= irreversible
    • asymptomatic
    • serious & fatal
  8. what happens during end stage cirrhosis of portal cirrhosis
    • fibrotic tissue replaces normal tissue
    • minimal normal function of liver
  9. what causes billiary cirrhosis
    chronic inflammed bile ducts from gallstones or cystic fibrosis
  10. what Hepatitis is associated with postnecrotic cirrhosis
    B & C
  11. what causes metqabolic cirrhosis
    • storage disorders
    • hemochromatosis(Decreased iron metabolism, iron accumulates in liver)
  12. what are the early signs and symptoms of cirrhosis
    • fatigue, anorexia, nausea, indigestion, diarrhea, weight loss
    • anemia
    • leukopenia & thrombocytopenia
    • splenomegaly
    • URQ pain dull aching
  13. as cirrhosis progresses what occurs
    • portal vein blocked
    • blood backs up in,liver
    • portal hypertension
    • blood fromother organs that drain into portal vein blocked
    • blood flow backwards
  14. as cirrhosis progresse what are the signs
    • splenomegaly
    • esophageal varices=varicouis veins that rupture=hemorrage
    • ascities
    • hematemesis
    • hypoalbuminemia
    • jaundice
    • gynecomastia, testies atrophy, irregular menses
    • hepatic encephalopathy
    • puritis and peripheral neuritis
  15. what is ascities
    • swollen abdomin due to fluid in peritonal cavity
    • caused by poratl hypertension
    • decreases albumin synthesis
    • elevates aldosterone and ADH levels
  16. vomiting of blood
    hematesis
  17. describe hematemesis
    • liver cells don't secrete blood clotting proteins
    • decreased bile= decreased vitimin K absorption(neede for clotting factors)
    • thrombocytopenia
    • vomiting blood
  18. describe hypoalbuminemia
    • albumin deficiency
    • fluids leak
    • edema
  19. what are signs of hepatic encephalopathy
    • confusion
    • stupor
    • hand-flapping
    • coma
    • CNS effected
  20. describe pruritus & peripheral neuritis
    • biliary obstruction
    • bile salt in tissue
    • pruritus leads to scratching skin=infections
  21. what are the diagnostic test for cirrhosis
    • Physical exam
    • liver enlarged=alchol
    • liver shrunk=fulminant Hep
    • blood for elevated liver enzymes and bilirubin
    • laparoscopy(inspection of abdomen organs)
    • liver scan
    • liver biopsy
  22. what are the complications of cirrhosis
    • hemorrhage
    • portal hypertension
    • esophageal varices
    • carcinoma
    • hepatic encepholapothy
    • frequent infections
    • death
  23. what is the treatment for cirrhosis
    • pallative
    • vitamins
    • paracentesis_removes excess fluid from ascities
    • liver transplants
  24. what is the prognosis for cirrhosis
    poor

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Author:
tville01
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155059
Filename:
Chapter 20, Cirrhosis
Updated:
2012-05-21 16:44:34
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Chapter 20 Cirrhosis
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Chapter 20, Cirrhosis
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