These cells secrete what?
G - gastrin
I - CCK
S - secretin
D - somatostatin
Parietal - intrinsic factor and gastric acid
Chief - pepsinogen (converted to pepsin by H+)
Acute Pancreatitis Associations: Mnemonic BAD HHITS
B - Biliary (Gallstones)
A - Alcohol
D - Drugs
H - Hypertriglyceridemia
H - Hypercalcemia
I - Idiopathic
T - Trauma
S - Scorpion Stings
Name the pancreatic secretions and their main function
amylase - starch digestion
lipase - fat digestion
proteases (trypsin, chymotrypsin, elastase, carboxypeptidases) - protein digestion
What converts trypsinogen to trypsin?
Enterokinase/enteropeptidase from duodenum
What three substances are involved in carbohydrate digestion?
oligosaccharide hydrolase - brush border of intestine * RATE LIMITER
This disease is an autosomal recessive defect on chromosome 7 associated with thick mucus production due to abnormal protein folding. Name the disease, gene mutation and treatment.
CFTR gene mutation
Tx: N-acetylcysteine (also used in acetominophen OD).
What are the two most common causes of acute pancreatitis?
Gallstones and alcohol
Elevation of CA19-9 and CEA are associated with what disease?
These signs usually show up with what disease?
Abd pain radiating to back, weight loss, migratory thrombophlebitis (Trousseau's sign) and obstructive jaundice with palpable gallbladder (Courvoisier's sign)?
What enzyme catalyzes the rate limiting step in carbohydrate synthesis?
When intestinal biopsy shows transmural inflammation - what is the typical diagnosis?
A weight lifter undergoes emergency surgery for a life threatening condition. Examination of small bowel shows focal hemorrhages. What is the process?
Encarcerated inguinal hernia (weight lifter)
What is the typical presentation of pancreatic insufficiency? What is the treatment?
Tx: Limit fat intake, replace enzymes
What is a Schilling Test? What are the 3 stages?
Radiolabeled cyanocobalamin to determine B12 absorption
1) without intrinsic factor
2) with intrinsic factor
3) with pancreatic enzymes
Describe how B12 is absorbed.
1) Pepsin releases B12 in stomach
2) B12 binds R binders
3) B12/R binder complex broken down in duodenum
4) B12 binds Intrinsic Factor
5) B12/IF complex hits receptors in terminal ileum
6) Transcobalamin II picks up B12 in plasma
What serum antibodies are associated with celiac sprue?