pathogenicity

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Author:
andreathors16
ID:
155288
Filename:
pathogenicity
Updated:
2012-05-22 17:14:29
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microbiology
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final exam
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  1. pathogenicity
    the ability of a pathogen to produce disease by overcoming host defenses
  2. virulence is
    • the degree of pathogenicity
    • expressed as LD50 (lethal dose necessary to kill 50% of inoculated hosts)
  3. ID50
    dose necessary to infect 50% of inoculated hosts
  4. portal of entry
    • rount of entry
    • eyes, respiratory tract, gastrointestinal tract, genitourinary tract
    • through mucous membranes
  5. respritatory tract
    • most comon
    • inhaled on moisture droplets or dust particles
  6. genitournary tract
    moucous membranes and direct contact
  7. gastrointestinal
    through food, water, and contaminated fingers
  8. skin
    through hiar follicles and sweat ducts
  9. parenteral
    • through inoculation
    • insect bites, injection and wounds
  10. host defense
    bacterial elements that overcome host defenses
  11. capsules
    • prevent or reduce phagocytosis
    • polysaccharide
  12. cell wall components
    adhesions to complementary receptors on host cells
  13. fimbriea
    interact with membrane glycoprotiens
  14. leukocidins
    destroy white blood cells
  15. hemolysins
    destroy red blood cells
  16. kinases
    digest blood clots
  17. hyluronidase
    digest mucopolysacharides
  18. collogenase
    destroy collogen of connective tissue
  19. cell cytoskeloton
    • invasions cause actin of microfilaments to form baskets to carry bacteria into the cell
    • salmonella
  20. damage host cells by
    • metabolizing and reproducing in hosts
    • and production of toxins
  21. exotoxins
    • from gram + bacteria, secreated protien product
    • heat liable (60 to 80 deg c)
    • toxic: low LD50
    • specific for cell type and cell function
  22. diptheria toxin
    stops protien synthesis and damages heart/other organs
  23. cholera toxin
    affects intestinal cells, dirupts cAMP- a cells secondary messanger
  24. tetnus toxin
    affects nerve transmission
  25. toxic shock
    affects tcells and macrophages
  26. listeriolysis
    pore forming cytotoxin allows cell to escape phagocytic vesicle
  27. endotoxins
    • gram-
    • present in LPS and released with destruction of cell
    • heat stable- can withstand an autoclave
    • not neutralized by antibodies
    • produces fever, aches shock
    • larger LD50
  28. typhoic fever
    week lps induced release of cytokinesis enter blood and multiply in spleen and liver
  29. typhimurium
    • food borne gastroenteritis
    • symptoms appear in 24 to 48 hours

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