S3M1 path2

Home > Preview

The flashcards below were created by user sweetlu on FreezingBlue Flashcards.


  1. Image Upload
    • Extracellular hyaline
    • - homogenous glassy, pink appearance (H & E)
    • - old scars may appear hyalinized
    • - walls of arterioles may become hyalinized- deposition of BM material
  2. Image Upload
    • Hyaline accumulation
    • - staining with PAS and diatase digestion(hydrolyzing glycogen)
    • - hyaline droplets are distinguishable as little pink droplets
  3. Image Upload
    • Excessive IC deposits of glycogen
    • - abnormality in glucose or glycogen metabolism
    • - Best carmine stains for glycogen (rose to violet color)
    • - clear vacuoles within cytoplasm
    • - fixed with absolute alcohol
  4. Image Upload
    • Glycogen in renal tubules seen in DM (H & E stain)
    • - with DM glycogen found in renal tubular epithelial cells, liver, heart muscle and beta cells of pancreas
  5. Image Upload
    glycogen storage disease stained with PAS
  6. Image Upload
    pigment (carbon) deposition from anthrocosis or air pollution
  7. Image Upload
    • Lipofuscin deposition (yellow-brown granule)
    • - endogenous, insoluble wear and tear pigment
    • - telltale sign of free radical damage
    • - not injurious to cell or function
    • - liver and heart of aging patients
    • - also seen in severe malnutrition and cancer cachexia
  8. Image Upload
    • Hemosiderosis
    • -IC Fe accumulation
    • - Seen in increase Fe intake, hemolytic anemia, repeated blood transfusions (beta- Thal patient)
  9. Image Upload
    Prussian blue stain of hemosiderosis
  10. Image Upload
    • Psammona bodies
    • - dystrophic calcification that may form in papillary cancers
    • - IC, EC or both locations
  11. Image Upload
    • Heterotopic bone
    • - dystrophic calcification
    • - IC, EC or both
    • - basophilic, amorphous, granular, sometimes clumper appearance
  12. Image Upload
    • Metastatic calcification of the lung
    • 4 principal causes of hypercalcemia
    • - increased PTH - destruction of bone tissue
    • - vit D related issue - renal failure
  13. Major components of acute inflammation
    • - vasodilation(histamine & NO)=>increased blood flow
    • - leakage from microvasculature (exudate= plasma+proteins)
    • - leukocyte immigration (mostly n0)
  14. endothelial injury
    • - occurs in arterioles, capillaries and venules
    • - caused by burns and some microbial toxins
    • - rapid and may be long lived (hours to days)
  15. leukocyte-mediated vascular injury
    • - in venules and pulmonary capillaries
    • - associated with late stages of inflammation
    • - long lived
  16. increased transcytosis
    • occurs iin venules
    • induced by VEGF
  17. Image Upload
    • Lymphangitis
    • inflammation of lymphatics
    • red streaks seen clinically near skin wound
  18. Image Upload
    • Lymphadenitis
    • painful inflammation and enlargement of draining lymph nodes
    • hyperplasia of lymphoid follicles
    • increased lymphocytes and macrophages
  19. Image Upload
    Lymphadenitis
  20. n0 migration thru blood vessels
    • 1- rolling= P-selectin, E-selectin, (enodthelial expressed)
    • 2- integrin activation by chemokines= proteoglycan
    • 3- stable adhesion- integren:ICAM-1
    • 4- diapedisis- PECAM-1(CD31)
  21. Image Upload
    • L- n0 inflammatory infiltrate seen early in inflammation
    • M- mononuclear(lymphocytes and monocytes) seen later
  22. bactericidal/permeability increasing protein
    • binds bacterial endotoxin
    • important in defense against some G- bacteria
  23. alternatively activated macrophages
    • important in tissue repain (arginase, proline, polyaminases and TGF-beta
    • important in resolution of inflammation (IL-10, TGF-beta)
  24. abscess
    - always neutrophils
  25. prostacyclin (PGl2)
    • causes vasodilation
    • inhibits platelet aggregation

    cell derived mediator
  26. Thromboxane A2 (TXA2)
    • causes vasoconstriction
    • promotes platelet aggregation

    cell derived mediator
  27. PGD2 and PGE2
    • vasodilation
    • increased vascular permeability

    cell derived mediator
  28. Lipoxin- LXA4 and LXB4
    inhibits neutrophil adhesion and chemotaxis
  29. 5-HETE
    chemotaxis
  30. Leukotriene B4 (LTB4)
    • vasoconstriction
    • bronchospasm
    • increased vascular permeability
  31. NO
    cell derived
    • inhibits cellular component of inflammatory response
    • microbicidal
    • inhibits leukocyte recruitment
    • inhibits many features of mast cell-induced inflammation
    • causes vasodilation
    • reduced platelet aggregation and adhesion
  32. PAF
    cell derived
    • vasoconstriction and bronchoconstriction
    • vasodilation and increased vascular permeability at low concentrations
    • increased WBC adhesion to endothelium
    • chemotaxis, degranulation and oxidative burst
    • boosts eicosanoid synthesis
  33. LAP stain
    • leukocyte ALP staining
    • differentiates between leukomoid and leukemia
    • LAP+= leukomoid
    • leukemia cells are in arrested development
  34. chronic inflammation characteristics
    • infiltration with mononuclear cells (m0, lymphocytes, plasma cells)
    • tissue destruction (induced by offending agent and inflammatory cells)
    • healing by connective tissue replacement of damaged tissue (angiogenesis and scarring)
  35. Image Upload
    • Plasma cell
    • Russel bodies present (RER and proteins
  36. Image Upload
    • Eosinophil
    • IgE mediated immune reaction
    • helmith/parasitic infections
    • granules contain major basic protein
    • causes lysis of mammalian epithelial cells
    • contribute to tissue destruction in allergies
  37. Image Upload
    • serous inflammation
    • blister from burn or viral infection
  38. Image Upload
    • caseous granuloma
    • classic TB granuloma with central caseous necrosis surrounded by mutliple Langerhan cells, epitheloid cells and lymphocytes
    • - seen in TB, syphillis and cat-scratch disease
  39. Image Upload
    • non caseous granuloma
    • - leprosy, sarcoidosis and Chrons

Card Set Information

Author:
sweetlu
ID:
155721
Filename:
S3M1 path2
Updated:
2012-06-05 22:41:01
Tags:
S3M1 path2
Folders:

Description:
S3M1 path2
Show Answers:

Home > Flashcards > Print Preview