pharm - HEENT derm.txt

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  1. too much estrogen
    HTN, melasma, nausea
  2. too little estrogen
    early/mid-cycle breakthrough bleeding, increased spotting, hypomenorrhea
  3. too much progestin
    fatigue, changes in mood
  4. too little progestin
    late breakthrough bleeding
  5. most potent progestin
    desogestrel, levonorgestrel, norgestrel
  6. least potent progestin
  7. most androgenic progestin
  8. least androgenic progestin
    desogestrel, norgestimate
  9. anti-androgenic progestin
  10. only four-phasic pill
    Natazia (estradiol valerate + dienogest)
  11. 365 day a year pill
    Lybrel (ethinyl estradiol + levonorgestrel)
  12. oxytocin (Pitocin) interaction
    simpathomimetics (increased risk of severe HTN)
  13. oxytocin BBW/caution
    not for elective labor induction. hypotension c rapid infusion.
  14. reproductive prostaglandins (PGE1, PGE2, PGF2a)
    misoprostol (Cytotec), dinoprostone (Hemabate), carboprost
  15. reproductive prostaglandins indications (PGE1/PGE2; PGF2a)
    labor induction and cervical ripening; postpartum hemorrhage (not first line)
  16. reproductive prostaglandins BBW/contraindications
    not for pregnant pts (abortion), women of child-bearing potential. contraindicated c severe asthma, glaucoma, MI.
  17. antitussives: centrally acting
    dextromethorphan, codeine (Cheratussin AC), hydrocodone
  18. antitussives: peripherally acting
    camphor, menthol, benzonatate (Tessalon)
  19. demulcent
    soothing agent
  20. dextromethorphan interaction
    dextromethorphan + MAOI (seritonin storm)
  21. benzonatate BBW
    severe hypersensitivity rxns (bronchospasm, laryngospasm, CV collapse) possibly related to local anesthesia from sucking/chewing capsule instead of swallowing it
  22. expectorants
  23. decongestants: direct alpha-1 agonists (work best topically)
    phenylephrine, oxymetazolone (opthalmic Visine), naphazoline (opthalmic Naphcon/Visine A)
  24. decongestants: indirect alpha-1 agonists (work best orally)
    pseudoephedrine, ephedrine
  25. decongestant interactions
    decongestant + MAOI (hypertensive crisis)
  26. rebound congestion
    Rhinitis Medicamentosa
  27. H1 antagonists: first gen
    chlorpheniramine, brompheniramine, cyproheptadine, clemastine
  28. H1 antagonists: second gen
    loratadine (Claritin), cetirizine (Zyrtec), fexofenadine (Allegra)
  29. fexofenadine dosing
    Allegra: 60mg PO BID or 180mg PO qd
  30. Cherratussin AC dosing
    codeine/guaifenesin 10/100/5mL, 10-20mg codeine (1-2 tsp) PO q4-6h PRN
  31. dual antihistamine/mast cell stabilizer
    epinastine (Elestat)
  32. Mast Cell Stabilizers
    cromolyn. opthalmic nedocromil and lodoxamide.
  33. Opthalmic Prostaglandins
    latanoprost (Xalatan), travoprost (Travatan), bimatoprost (Lumigan)
  34. Opthalmic Prostaglandins MOA
    increase intraocular outflow via uveoscleral route (not Schlemm's canal)
  35. latanoprost dosing
    Xalatan, 1ggt in eye(s) qpm
  36. Aptamers
    pegaptanib (Macugen)
  37. pegaptanib MOA
    Macugen: binds to vascular endothelial growth factor, inhibiting the proliferation of blood vessels and reducing blood vessel permeability/leakage
  38. pegaptanib dosing
    injected directly into the eye!
  39. Topical Corticosteroids super-high
    super-high: clobetasol (Temovate) 0.05%
  40. Topical Corticosteroids high
    high: fluocinonide (Lidex) 0.05%
  41. Topical Corticosteroids medium
    medium: triamcinolone acetonide (Kenalog) 0.1%
  42. Topical Corticosteroids low
    low: fluocinolone acetonide 0.01%, desonide 0.05%, hydrocortisone 1%
  43. Benzoyl peroxide MOA
    both antibacterial and comedolytic properties. penetrates the stratum corneum or follicular openings where it is converted to benzoic acid.
  44. Benzamycin
    benzoyl peroxide + erythromycin
  45. BenzaClin
    benzoyl peroxide + clindamycin
  46. Epiduo
    benzoyl peroxide + adapalene
  47. Benzoyl peroxide c oral antibiotics (TCAs)
    combo helps prevent antibiotic resistance. No go in pregnancy.
  48. Azelaic acid brand
    gel form = Finacea, cream - Azelex
  49. Topical Antifungals: both candida/dermatophytes
    imidazoles (fungastatic) ("azoles")
  50. Topical Antifungals: dermatophytes only
    allylamines and benzylamines (fungicidal) ("afines")
  51. Topical Antifungals: candida only
    polyenes (fungistatic) (nystatin)
  52. Topical Vitamin D analogs
    calcipotriene, calcitriol
  53. Topical Vitamin D MOA
    inhibit keratinocyte proliferation
  54. Taclonex
    calcipotriene/betamethason (Vitamin D analog/anti-immune)
  55. Keratolytics
    salicylic acid, lactic acid, urea
  56. imiquimod MOA
    modifies immune response to skin (increases inflammation in dermis -> eradication of abnormal cells)
  57. imiquimod indications
    actinic keratoses, basal cell carcinoma, genital/perianal warts
  58. imiquimod dosing
    16 wks max (6 wks for BCC)
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pharm - HEENT derm.txt
2012-05-28 16:24:08
pharm HEENT derm

pharm - HEENT derm.txt
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