chemotherapy

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Author:
saurasauras
ID:
156630
Filename:
chemotherapy
Updated:
2012-05-31 13:05:18
Tags:
chemo
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Description:
chemotherapy
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  1. Carboplatin
    • Mechanism: exact unknown, but may form DNA cross links. (DNA alkylator)
    • Dose 300-400 mg/m2. q4 weeks
    • Renally excreted
    • Primary toxicity: Thrombocytopenia, leukopenia, nausea, vomitting.
    • Secondary toxicity: Renal, peripheral neuropathy
  2. Cisplatin
    • Mech: Formation of intra-structural DNA cross links
    • Dose: 50-120 mg/m2 q3-4 weeks
    • Elimination 90% renal, 10% billary
    • Toxicity: primary - Leukopenia, anemia, renal, ototoxicity, peripheral neuropathy
    • secondary: decreased levels of Na, K, Ca and Mg, anaphylactoid reactions
  3. Ifosfamide
    • Uses: Sarcoma, ovarian and cervical cancer
    • Mechanism: DNA cross links
    • Dose: 1.2 gm/m2/day for 5 days, q21-28 days
    • Renal excretion, required hepatic metabolism to become active
    • Toxicity:
    • Primary: Hemorrhagic cystitis (acrolein), myelosupression, N/V, alopecia
    • Secondary: Nephrotoxicity, CNS toxicity, SIADH
  4. Bleomysin
    • Antibiotic, complexes w/ Fe to form oxidase and in turn free radicals which results in DNA strand breaks w/ cells most suseptible in the G2 and mitotic phases. Therefore is cell cycle specific.
    • Dose: 10 mg/m2/day for 4 days, q4wks
    • Renal excretion
    • 1 - Fever, interstitial pneumonitis (10%), pulm fibrosis (1%), stomatitis. Keep dose < 400 u as pulm fibrosis occurs above this level. A 30-35% change in DLCO - d/c
    • 2- n/v myelosupression

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