Role of oxygen in wound healing?
Initially the wound is hypoxic because of vasoconstriction and clot formation. inflammation greatly increases blood flow and oxygenation. Inflammation also induces an influx of many new cells resulting in hypoxia, hypercarbia, and acidosis. Collagen synthesis and polymerization is an oxygen requiring process so any process that reduces oxygen uptake will reduce the rate of healing (ex: smoking, anemia, lung disease).