Card Set Information
MLT 10005, WBC, anomalies
congenital or hereditary condition where the WBC's dviate from the normal standard.
This is an autosomal dominant, that causes an abnormal maturation of nucleus that appears to function normally.
Inherited (true) pelger-huet
This pelger-huet condition may be drug induced or secondary to CML.
in pseudo-pelger-huet ____ are normal three lobed nucleus.
This is a response to severe infection where metamyelocytes and bands are present.
Shift to the left
These are blue staining areas made up of rough endoplasmic reticulum and RNA.
This is an autosomal dominant condition where dohle bodies, throbocytopenia, and giant, bizarre platelets are seen.
This is a rare sex-linked recessive disease that is fetal at a young age due to WBC's being unable to kll catalase positive organisms.
this disorder is characterized by a normal WBC morphology, increased WBC count and granulomas in many organs and sites of infection.
This is a deficiency of enzyme beta-glucocerebroside.
What are the five characteristics of gaucher's disease?
gaucher's cells in bone marrow
increased serum acid phosphate
In bone marrow these cells have a wrinkled cytoplasm that looks like unfolded crumpled paper.
These tissue cells are also known as sea-blue histiocytes.
these disorder is caused dby a deficiency in sphingomyelinase that leads to an accumulation of sphingomyelin in histiocytes.
infectious mononucleosis is caused by what virus?
Epstein Barr Virus
The epsein barr virus infects what cells?
how is infectious mononucleosis contracted
infectious mononucleosis causes malaise, enlarged lymph nodes, splenomegaly, hepatomegaly, and is known as a _______ illness.
Complete recovery from infectious mononucleosis usually takes _______.
This is an abnormal neutrophilic response to infection that mimics early stage or leukemia.
These are dark blue-black granules seen in severe bacterial infections.
What are the four laboratory features of a leukemoid reaction.
signs of infection
in a leukemoid reaction what is the:
In CML what is the:
This is a malignant disease of hematopoietic tissue.
In leukemia normal bone marrow elements are replaced by ________.
in leukemia __________ is always involved.
Lukemia infiltrates what three parts of the body.
: all ages
: immature (blasts)
: mild to severe
Thrombocytopenia :mild to severe
In Chronic lukemia
If the liver and spleen are not affected by acute leukemia what anemia will be present?
what cells will be present and usually predominante in an acute leukemia patients differential?
This is used to attain better discrimination in therapy and prognosis
FAB classification is based on what four things?
immunologic marker studies
what type of blast has prominent nucleoli and and auer rods present in 50-60%.
what type of blast has indistinct nucleoli and never has auer rods.
These are stains used to aid in the diagnosis and classification of leukemia.
Cytochemical staining uses the presence or absence of ________ or ________ to differentiate hematopoietic cells.
This leukemia resembles M1 except smear shows maturation to or beyond promyelocytes.
What is the most common type of AML
M1 and M2
True or False
auer rods are often present in M2
in this leukemia cells are all promyelocytes
what type of leukemia has cells that have a kidney shaped or biloben nucleus, moderate cytoplasm, heavy primary granulation, and auer rods are common and in multiple
what type of leukemia has a high incidence of DIC.
in M4 leukemic cells are called _______.
what type of leukemia is is characterized by both monocytic and granulocytic differentiation.
what type of leukemia has a large heterogenous lymphoblast morphology.
what is the four characteristics of nucleus lymphoblast morphology in L2-ALL.
irregular in shape
clefting and indentation
heterogenous chromatin pattern
one or more nucleoli
what are the two characteristics of a laymphoblast's cytoplasm.
variable, often moderately abundant
variable cytoplasmic vacuolization
what is B cell ALL aso called?
burkitt's leukemia or lymphoma
this leukemia accounts for 2-5% of all ALL cases and has asymmetrical enlargement of lymph nodes.
what are the two other names that Chronic Myelogenous Leukemia is known as?
Chronic Myeloid Leukemia
Chronic Myelocytic Leukemia
This is the most common type of leukemia in adults.
what are the five symptoms of CML?
This is a diverse group of diseases characterized by proliferation of a single clone of cells producing a monoclonal immunoglbulin or immunoglobulin fragments.
Plasma Cell Disorders
What are the three causes of multiple myeloma?
Chemical agents (agricultural)
certain medical conditions
True or false
Multiple myeloma is not normally a myloproliferative disorder
this disorder causes bone pain in 2/3 of cases, anemia, fatigue, SOB, constipation, and abdominal pain.
This disorder involves IgG or IgA, and causes marked rouleaux, elvated ESR, Presence of flame cells in BM
This disorder is characterized by a predominance of prolymphocytes in bone marrow and marked rouleaux
this dye is used to differentiate AML or AMoL from ALL. Positve for AML and AMoL (blue-black precipitate). Negative for ALL (No precipitate)
This stain is soluble in lipids and penetrates granules in granulocytes and monocytes. granules stain black.
Sodium fluoride inhibits this dye's activity in monocytes and macrophages but not other cells.
Acute Promyelocytic Leukemia