Immunity

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Author:
ambirc
ID:
157948
Filename:
Immunity
Updated:
2012-06-09 13:55:07
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pharm path immunity
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  1. Immunity
    • the
    • ability of the body to defend itself against infectious agents, foreign cells,
    • and abnormal body (cancer) cells
  2. 3 possible potential triggers that cause an
    immune response
    • ·
    • infectious agents, foreign cells, and abnormal body (cancer) cells.
  3. Naturally acquired immunities
    • acquired
    • through infection – i.e. chicken pox
  4. Artificially Acquired immunities
    • acquired through
    • immunization – polio vaccine
  5. Nonspecific or innate immunity
    • Present at birth providing
    • immediate but general protection
  6. Specific or acquired immunity
    effective versus specific foreign agent; develops in response to contact with that agent, once established will responds to future exposures of same agent
  7. Cells in Nonspecific or innate immunity
    • Dendrite Cells
    • Mast Cells
    • Granulocytes – Basophils, Eosinophil’s, Neutrophils
    • Natural Killer Cells
    • Macrophages
    • Complement Protein
  8. Cell in Specific or acquire immunity
    B Cells (lymphocytes)

    B and T Cells

    T Cells –CD4+ T Cell and CD8+ T Cell
  9. BOTH Specific/innate and Specific/acquired immunity
    • gd T Cells – Migrate to the
    • body tissue especially epithelia – function unknown

    Natural Killer T cells – respond to infectious agents
  10. differentiate the roles of B and T cells
    (lymphocytes
    • Each B and T cells are
    • specific for a particular antigen, meaning each is able to bind to a particular
    • molecular structure
    • B Cells: Produced
    • in the bone marrow; antibody formation; Immunoglobins
    • T Cell: Produced
    • in the bone marrow, but mature in the thymus; there are 2 subset CD4+ and CD8+
  11. What imuneoglobins are produced in B cells?
    IgA, IgD, IgE, IgG, IgM
  12. What are the two subsets of T Cells
    CD4+ CD8+
  13. CD4+ Cells
    • Part of class II histocompatibility molecules (if a person is a good candidate for an organ transplant)
    • Only Specialized antigen-presenting cells express class II
    • molecules (i.e dendrite, macrophages, B Cells)
    • Essential for both cell and antibody mediated immunity
  14. CD8+ Cells
    • Part of class I histocompatibility molecules and almost all cells of the body express class I molecules
    • AKA Cytotoxic T lymphocytes
  15. What comprises histocompatibility molecules
    • Protein expressed at the surface of almost all the vertebrate cells
    • Responsible for the compatibility or lack of it, such as tissues form genetically different people
  16. Be able to categorize histocompatibility molecules
    • Monozygotic (identical human twins) – have the same histocompatibility molecules on their cells; can accept tissue transplant from each other
    • Non-monozygotichumans – Have a unique set of histocompatibility molecules; graft tissue between non-monozygotic humans will provoke and immune response;
    • histocompatibility molecules of one individuals act as antigens to a different individual; left unchecked, will end in the rejection of the transplant
  17. list the role of the six mechanisms in nonspecific (innate) immunity
    • Physical or chemical barriers
    • Phagocytosis
    • Natural Killer Cells
    • Fever
    • Interferon
    • Inflammation

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