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Metoclopramide is a Dopamine antagonist similar to procainamide, but with few anti-dysrhythmic or anesthetic properties. Its anti-emetic properties stem from gastric emptying and desensitization of the vomiting reflex.
Nausea and vomiting
Hypersensitivity, seizure disorders, GI obstruction or perforation, and breast cancer.
CHF, hypokalemia, renal impairment, GI hemorrhage, intermittant porphyria.
- - Dosage/Route: 10 - 20 mg IM; 10 mg slow IV (over 2-4 minutes)
- Pedi: 1-2 mg/kg/dose
Promethazine is an anticholinergic agent that enhances the effects of analgesics and potent anti-emetic.
Nausea and Vomitting, motion sickness, enhance effects of analgesics, and to induce sedation.
Hepatic, respiratory, or cardiac impairment, asthma, hypertension, elderly, debilitated patients.
- - Dosage/Route: 12.5-25 mg IV/IM/PR
- Pedi: 0.5 mg/kg IV/IM/PR
: Prochlorperazine is a phenothiazine derivative similar to chlorpromazine with potent antiemetic properties and fewer sedative, hypotensive, and anticholinergic effects.
: Severe nausea and vomiting or acute psychosis.
- - Contraindications: Hypersensitivity to
- phenothiazines coma or depression.
: Breast cancer, children with acute illness or dehydration
- - Dosage/Route: 5 to 10 mg IV/IM.
- Ped: 0.13 mg/kg IV/IM/PR if > 10 kg or > 2 years.
- Description: selective blocking agent of seratonin 5-HT3 receptor type
- Indications: Prevention of nausea and intractible vomiting.
- Contraindications: None
- Precautions: may mask a progressive ileus and/or gastric distension.
- Dosage/Route: 4 mg IV or PO