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evelngo
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Class I anti-arrhythmics block which channels?
Sodium Channels
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Class II anti-arrhythmics block which channels?
Calcium channels (indirect effect)
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Class III anti-arrhythmics block which channels?
Potassium channels
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Class IV anti-arrhythmics block which channels?
Calcium channels
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Although Amiodarone is considered a class III anti-arrhythmic, what other channels does it block?
Sodium and Calcium channels
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List Class Ia anti-arrhythmics:
- - Quinidine gluconate/sulfate/polygalacturonate
- - Procainamide
- - Disopyramide
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List Class Ib anti-arrhythmics:
Lidocaine
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List Class Ic anti-arrhythmics:
- - Flecainide
- - Propafenone
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List class II anti-arrhythmics:
- Beta-blockers:
- -Metoprolol
- -Esmolol
- -Propranolol
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List class III anti-arrhythmics:
- -Sotalol
- -Amiodarone
- -Ibutilide
- -Dofetilide
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List class IV anti-arrhythmics:
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Micellaneous anti-arrhythmics:
- Atropine
- Adenosine
- Digoxin
- Donedarone
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Quinidine GLUOCONATE (5)
- Quinaglute, Dura-Tabs, Duraquin, Quinalan, Quinatime
- (not recommended IV)
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Quinidine SULFATE (4)
Quinidex, Extentabs, Cin-Quin, Quinora
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Quinidine POLYGALACTURONATE
Cardioquin
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Amiodarone (3)
Cordarone, Pacerone, Nexterone
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Digoxin
Lanoxin, Lanoxicaps
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If AF is present for > 48 hours or unknown duration, anticoagulat with warfarin for _____ weeks prior to cardioversion, and continue for at least _____ weeks after sinus rhythm has been restored.
3; 4
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Prior to cardioversion, patients must receive _____ or ______. Once sinus rhythm restored, patients should receive warfarin for at least _______ weeks.
Unfractionated heparin; Low molecular weight heparin; 4
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What does CHADS2 score represent?
It determines the risk of stroke in patients with AF
- C = CHF = 1 point
- H = HTN = 1 point
- A = Age over 75 = 1 point
- D = Diabetes = 1 point
- Stroke or TIA = 2 points
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What are the treatments recommended for a score of 0, 1, and >/equal to 2.
- 0 = ASA 81-325 mg/day
- 1 = 81 - 325 mg/day OR warfarin INR 2-3
- >2 = warfarin INR 2-3
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If patient do not want to take warfarin or if risks outweigh benefits, addition of ___________ can be added to ASA therapy.
Clopidogrel
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Which two genes account for variablity in warfarin therapy if mutated?
CYP2C9 & VKORC1
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