Ischemic Heart Disease

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Author:
evelngo
ID:
159605
Filename:
Ischemic Heart Disease
Updated:
2012-07-30 15:16:57
Tags:
IHD
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Description:
Brand/Generic
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  1. What is the door-to-needle time GOAL (time from which patient enters ER to time of IV administration) for fibrinolytic therapy?
    30 minutes
  2. T/F: PCI is preferred over fibrinolytic therapy for patients presenting within 3 hours of symptom onset where the delay to PCI would be > 90 minutes.
    False. Fibrinolytic therapy is preferred.
  3. T/F: Fibrinolytic therapy is indicated when presentation is within 12 hours of symptom onset.
    True. It should NOT be used if time to therapy is >24 hours.
  4. T/F: NON-fibrin specific agents are preferred over fibrin specific agents?
    False. Fibrin specific agents are preferred.
  5. Name the fibrin-specific fibrinolytics:
    • Tenecteplase
    • Alteplase
    • Reteplase

    Think of fibrin as "sticky TAR"
  6. Reteplase
    Retevase
  7. Streptokinase
    Stretase
  8. Teneteplase
    TNKase
  9. tPA
    Alteplase
  10. Clopidogrel
    Plavix
  11. Prasugrel
    Effient
  12. Ticlopidine
    Ticlid
  13. T/F: Plavix and Effient are preferred over Ticlid due to mroe favorable side effect profiles.
    True.
  14. T/F: The MOA of platelet aggregation for thienopyridine and Aspirin are the same.
    FALSE
  15. Abciximab
    ReoPro
  16. Eptifibatide
    Integrelin
  17. Tirofiban
    Aggrastat
  18. Early management of ACS includes _____ (5 things)
    • Morphine,
    • Oxygen
    • Nitroglycerin
    • ASA
    • B-Blocker
  19. Bivalirudin (Angiomax) is a direct __________ inhibitor.
    thombin
  20. Fondaparinux (Arixtra) binds to ___________ and potentiates the inhibition of ____________.
    antithrombin III; Factor Xa
  21. What is the MOA of thienopyridines?
    Blocks ADP mediated activation of platelets by blocking ADP activaton of glycoprotein IIb/IIIa complex.
  22. Which drugs are considered thienopyridines (3)?
    • Clopidogrel (Plavix)
    • Prasugrel (Effient)
    • Ticlopidine (Ticlid)
  23. Which drugs are GIIb/IIIa inhibitors?
    • Eptifibatide (Integrelin)
    • Abciximab (ReoPro)
    • Tirofiban (Aggrastat)

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