Drug Interactions

Card Set Information

Author:
adguvetis
ID:
161555
Filename:
Drug Interactions
Updated:
2012-07-08 17:56:00
Tags:
Pharmacy
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Description:
Summary of significant drug interactions.
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  1. Major CYP 450 Inducers
    • PS PORCS
    • Phenytoin
    • Smoking
    • Phenobarbital
    • Oxcarbazepine
    • Rifampin
    • Carbamazepine
    • St. John's Wort 
  2. Major CYP 450 Inhibitors
    • G PACMAN
    • Grapefruit
    • PIs
    • Azole Antifungals
    • Cimetidine
    • Macrolides
    • Amiodarone
    • Non-DHP CCBs 
  3. Must decrease dose 30-50% when starting amiodarone
    • Digoxin
    • Warfarin
    • Quinidine
    • Procainamide 
  4. Antifungals with pH dependent absorption: High pH causes decreased absorption
    • Itraconazole
    • Ketoconazole 
  5. Digoxin is mostly _____ cleared and partially _____ cleared.
    • 1. Renally
    • 2. Hepatically 
  6. Hypokalemia (K+< 3.5 mEq/mL) will ________ digoxin levels.
    Increase
  7. Increased risk of severe rash. Use caution and titrate slowly.
    • Lamotrigine
    • Valproate 
  8. Increases Lithium levels
    • Decreased salt intake
    • NSAIDs
    • ACEI/ARBs
    • Dehydration (caution with diuretics) 
  9. Decreases Lithium levels
    • Salt intake
    • Caffeine
    • Theophylline 
  10. Decreases levels of OCs
    • Antibiotics
    • Anticonvulsants
    • St. John's Wort
    • Anti-retrovirals
    • Smoking 
  11. Chelate with Al, Mg, Ca, Fe, and Zn
    • Tetracyclines
    • Quinolones 
  12. Anticoagulant that is neither a substrate, inhibitor, or inducer of CYP 450 enzymes
    Dabigatran
  13. QT prolonging agents
    • Class Ia and III antiarrhythmics
    • Quinolones
    • Macrolides
    • Azoles
    • Anticancer agents
    • Protease inhibitors
    • Antidepressants (TCAs, SSRIs, SNRIs, trazodone)
    • 5-HT3 blockers
    • Antipsychotics 

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