micro cpt16 t4
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What makes CYCLOSPORINE an effective drug for transplant patients?
This drug SUPPRESSES the Cell Mediated immune system more that the Antibody Mediated immune system
Name the 4 typed of HYPERSENSITIVITY?
- TYPE I: Immediate
- TYPE II: Antibody Mediated Cytotoxic
- TYPE III: Immune Complex
- TYPE IV: Cell Mediate / Delayed
This refers to the response of Basophils and Mast Cells over reacting to antigens?
- When an antigen (Allergen particles) attaches to IgE that is on the membranes of B-cells (Mast cells), they release too much histamine which results in inflammation, runny nose, red itchy eyes?
This is susceptible to inheritance?
TYPE I or IMMEDIATE HYPERSENSITIVITY
An over reaction of the immune system that can lead to tissue damage or Death of the patient is refered to as ____?
This is a systemic anaphylactic shock caused by :
- drugs like penicillin
- insect venoms like bee sting
What injection is used to treat ANAPHYLAXIS?
Aprocedure that involves the injections of small amounts of antigen in the a host is refered to as______?
- This proedure initiates the production of IgG &IgA molecules that block the antigen from getting to the IgE on the MAST Cells?
A chronic local allegy such as :
- Hey fever
What causes disorders in the immune system?
Over reaction OR under reaction of the immune system
Name 2 methods of curing ANAPHYLAXIS?
Epinephrine & Desensitization
The response of IgG or IgM activation of the COMPLEMT SYSTEM results in ?
the activation of this system result in the formation of membrane attack complexes which leads to cell lysis.
This type of hypersensitivity is the CAUSE OF TRANSFUSION REACTIONS?
TYPE II or ANTIBODY MEDIATED CYTOTOXIC HYPERSENSITIVITY
WHAT HAPPENS WHEN A PATIENT IS GIVEN THE WRONG BLOOD TYPE?
The patient develops SYSTEMIC or KIDNEY FAILURE.
Hemolytic disease of NEW BORNS is an example of what type of hypersensitivity?
TYPE II or ANTIBODY MEDIATED CYTOTOXIC Hypersensitivity.
How can Hemolytic disease of New Borns be prevented?
By injecting the mother with RhoGAM
RhoGAm is compose of Anti-Rh antiserum
How does Hemolytic disease of New Borns occur?
This disease occurs when an Rh -ve mother has a second Rh+ve child.
-2+ = Rh
What are examples of type III (Immune Complex) hypersensitivity?
- - Systemic Lupus Erythematosus
- - Rheumatoid Arthritis
- - Multiple Sclerosis
- - Grave's disease
This herpersensitivity is inheriditary, and results from IgG & IgM specific for small circulating antigens which form complexes that activate complement on host tissues?
- It is opposite to Type I hypersensitivity?
TYPE III or IMMUNE COMPLEX HYPERSENSITIVITY
This type of heypersensitivity results from the immune system reacting to foreign antigens binding to patients's tissues or cells?
- the antigens are attacked by Marcrophages & T Cytotoic cells
TYPE IV or CEL MEDIATED HYPERSENSITIVITY
Name examples of type IV (Cell mediated /Delayed) hypersensitivity?
- CONTACT DERMATITIS: caused after hapten combines with protein in the skin of the host.
- TUBERCULIN REACTION: use to test for Tuberculsis.
What plays a major role in the Rejection of a GRAFTED organ?
T CYTOTOXIC CELLS and CELL MEDIATED IMMUNE SYSTEM
DAEFICIENCIES IN THE ACQUIRED SPECIFIC IMMUNE SYSTEM IS CALL ______?
IMMUNE DEFICIENCY diseases
This condition is genetically inherited and the person has the inability to produce ANTIBODIES?
- some are sex linked (mostly males)
- recurent serious bacteria infection
Name 3 eaxmples of immunodeficiency diseases?
- these diseases are heriditary?
- - AGAMMAGLOBULINEMIA
- - T-CELL DEFICIENCY
- - SEVERE COMBINED IMMUNODEFICIENCY
This disease is inherited and the patient cannot mount a cell mediated immune response?
These patients suffer from severe opportinistic infections and an increased risk of Cancer?
E.g: DeGeorge Syndrome
This disease is heriditary, and occurs when someone inherits both Agammaglobulinemia and T-cell Deficiency?
Patients cannot survive unless they are kept away from all micro organisms?
E.g: The Bubble boy disease
SEVERE COMBINED IMMUNODEFICIENCIES
What is the name of the drug that is given to prevent GRATED REJECTION?
- inhabits interleukins2 release,
- blocks activation of Helper T-cells
- prevents the production of T Cytotoxic cells
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