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- Alkylating agent, used in solid tumors
- causes hemorrhagic cystitis
- Peripheral and central neuropathies
- Alkylating agent
- Oto-, neuro-, nephro- toxicity
- Mucositis, dermatitis, cerebellar dysfxn
- Beta-1 adrenergic agonist
- Used to improve cardiac output in setting of pump failure
- + inotrope and peripheral vasodilator
- Minimal chronotrope --> minimal increase myocardial O2 demand
Drugs to prevent thyroid storm durid thyroidectomy
Ludol's solution 10 days preop
- (Not ok in pregnancy)
Causes bowel distention
- Depolarizing neuromuscular blocking agent
- Causes hyperkalemia, esp w/trauma, burns, infxns, neuromuscular dz
- Opioid agonist
- Causes hypotension
- Causes respiratory depression, esp in elderly
- Neuromuscular blocker
- Causes tachycardia
- Blocks IL-2 production from helper T cells.
- No clonal expansion of cytotoxic T cells.
- No Ab production from B cells.
- Arterial and venous vasodilator.
- SE: cyanide toxicity (high thiocyanate levels and low pH)
Increasing blood pressure in hypotensive patients with adequate fluid resuscitation.
- @ low levels: binds DA receptors in renal and splanchnic beds - increased urine output and natriuresis
- @ mid levels: binds cardiac beta-1 receptors - increased HR and contractility
- @ high levels: binds alpha receptors - increases BP and peripheral vascular resistance
Lithium - water balance
- ADH resistance
- Nephrogenic diabetes inspidus
- hypernatremia, dilute urine
Carbamazepine - water balance
- Intensifies renal response to ADH
- water retention
- hyponatremia + concentrated urine (like SIADH)
Hyperkalemia due to CHF drugs
- Drugs that reduce aldosterone or it's effects
- ACE Inh (prils)
- Angiotensin Receptor Blockers (sartans)
- Aldosterone antagonists (spironolactone, Eplerenone)
Hypertension drugs in pregnancy
- ACE Inh and ARBs = teratogenic
- Recommended = methyldopa, labetalol
- Avoid loop diuretics
- Essential HTN and BP <120/80: discontinue meds
- Essential HTN and BP >120/80: continue meds
- No previous meds and BP >150/95: start meds
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