Drugs.txt

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Author:
ruk2006
ID:
162350
Filename:
Drugs.txt
Updated:
2012-09-12 22:02:10
Tags:
Drugs
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Description:
Step 2 CK
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  1. Cyclophosphamide
    • Alkylating agent, used in solid tumors
    • causes hemorrhagic cystitis
  2. Bleomycin
    Pulmonary fibrosis
  3. Vincristine
    • Alkaloid
    • Peripheral and central neuropathies
  4. Cisplatin
    • Alkylating agent
    • Oto-, neuro-, nephro- toxicity
  5. 5-FU
    • Antimetabolite
    • Mucositis, dermatitis, cerebellar dysfxn
  6. Dobutamine
    • Beta-1 adrenergic agonist
    • Used to improve cardiac output in setting of pump failure
    • + inotrope and peripheral vasodilator
    • Minimal chronotrope --> minimal increase myocardial O2 demand
  7. Drugs to prevent thyroid storm durid thyroidectomy
    Ludol's solution 10 days preop

    • (Not ok in pregnancy)
    • Propylthiouracil
    • Methimazole
  8. NO2
    Causes bowel distention
  9. Succinylcholine
    • Depolarizing neuromuscular blocking agent
    • Causes hyperkalemia, esp w/trauma, burns, infxns, neuromuscular dz
  10. Morphine
    • Opioid agonist
    • Causes hypotension
  11. Midazolam
    • Benzo
    • Causes respiratory depression, esp in elderly
  12. Pancuronium
    • Neuromuscular blocker
    • Causes tachycardia
  13. Cyclosporine
    • Blocks IL-2 production from helper T cells.
    • No clonal expansion of cytotoxic T cells.
    • No Ab production from B cells.
  14. Nitroprusside
    • Arterial and venous vasodilator.
    • SE: cyanide toxicity (high thiocyanate levels and low pH)
  15. Dopamine
    Increasing blood pressure in hypotensive patients with adequate fluid resuscitation.

    • @ low levels: binds DA receptors in renal and splanchnic beds - increased urine output and natriuresis
    • @ mid levels: binds cardiac beta-1 receptors - increased HR and contractility
    • @ high levels: binds alpha receptors - increases BP and peripheral vascular resistance
  16. Lithium - water balance
    • ADH resistance
    • Nephrogenic diabetes inspidus
    • hypernatremia, dilute urine
  17. Carbamazepine - water balance
    • Intensifies renal response to ADH
    • water retention
    • hyponatremia + concentrated urine (like SIADH)
  18. Hyperkalemia due to CHF drugs
    • Drugs that reduce aldosterone or it's effects
    • ACE Inh (prils)
    • Angiotensin Receptor Blockers (sartans)
    • Aldosterone antagonists (spironolactone, Eplerenone)
    • Digoxin
  19. Hypertension drugs in pregnancy
    • ACE Inh and ARBs = teratogenic
    • Recommended = methyldopa, labetalol
    • Avoid loop diuretics
    • Essential HTN and BP <120/80: discontinue meds
    • Essential HTN and BP >120/80: continue meds
    • No previous meds and BP >150/95: start meds

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