Muscle Physiology

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Author:
geraldkristofferboy
ID:
162817
Filename:
Muscle Physiology
Updated:
2012-07-17 10:00:48
Tags:
Physiology 1st long
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Muscle Physiology
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  1. narrow, tapered rod-shaped cells; non-striated, uninucleated fibers; involuntary
    smooth muscle
  2. striated, tubular, branched uninucleated fibers; walls of the heart; involuntary
    cardiac muscle
  3. striated, tubular, multinucleated fibers; voluntary
    skeletal muscle
  4. capability of the muscle to respond to a stimulus
    excitability
  5. ability of a muscle to shorten and generate a pulling force
    contractility
  6. muscle can be stretched to their normal resting length and beyond to a limited degree
    extensibility
  7. ability of the muscle to recoil to its original resting length
    elasticity
  8. connective tissue covering group of fascicles
    epimysium
  9. connective tissue covering the fascicles
    perimysium
  10. connective tissue covering each of the muscle fibers
    endomysium
  11. basic rod-like unit of a muscle fiber
    myofibril
  12. cell membrane of muscle cell
    sarcolemma
  13. endoplasmic reticulum of the muscle cell
    sarcolemma
  14. invaginations of sarcolemma
    t-tubules
  15. portion of SR nearest the t-tubule; site of calcium release(contraction) and reaccumulation(relaxation)
    terminal cisternae
  16. composed of two terminal cisternae with t-tubule in between
    triad
  17. cytoplasm of muscle cell
    sarcoplasm
  18. light band
    I band
  19. dark band
    A band
  20. defines boundary of sarcomere
    Z-line
  21. light area present in the center of the sarcomere; has myosin thic filaments
    H zone
  22. center of sarcomere, contains proteins critical for organization and alighnment of the thick filaments
    M line
  23. also known as connectin, large protein that binds thick myosin filaments to the Z line
    titin
  24. extends along hte length of the thin filament and may participate in the regulation of the length of the thin filament; binds thin filaments to Z disc
    nebulin
  25. connects the z line to the connective tissue
    vinculin
  26. site for nebulin attachment
    alpha-actinin
  27. connects Z lines of 2 adjacent parallel sarcomeres
    desmin
  28. bundle of myosin proteins shaped like a double-headed golf club; connected to Z lines by titin
    myosin or thick filament
  29. formed by aggregation of actin molecules
    thin filaments
  30. extends over the entire actin filament and cover myosin binding sites on actin molecules in the absence of calcium
    tropomyosin
  31. binds/high affinity for calcium
    troponin c
  32. high affinity for actin; facilitates inhibition of myosin binding to actin by tropomyosin
    troponin i
  33. high/binds affinity for tropomyosin
    troponin t
  34. has myosin binding site; composed of g-actin molecule
    f-actin strand(fibrous)
  35. located at the end of the thin filament; may participate in setting the length of the thin filament
    tropomodulin
  36. structural link between the subsarcolemmal cytoskeleton of the muscle and the extracellular matrix; stability
    dystrophin
  37. power stroke is
    produced by:
    results into: 
    opening and closing of the nucleotide binding site

    rotation of regulatory domain to a fulcrum 
  38. low affinity calcium-binding protein; helps accumulate calcium in the terminal cisternae
    calsequestrin
  39. anchors calsequestrin near RYR; increases calcium buffering capacity at the site of calcium release
    triadin and junctin
  40. serves as a repid mobilizable reserve of energy-phosphate
    creatine phosphate

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