-
Alkylating Agents
P-nonspecific
-
Cyclophosphamide
(Cytoxan, CTX) BR, L, ALL
-
-
-
-
-
-
-
-
-
-
Antimetabolites
S-phase specific
-
fluorouracil
(5-FU, Adrucil) BR
-
Capecitabine
(Xeloda) BR ... prodrug of 5-FU
-
-
-
-
Fludarabine
ALL ... analog of 6-MP
-
-
Cladribine
...Hairy cell leukemia
-
Methotrexate
(MTX, Rheumatrex, Trexall) BR
-
-
Pralatrexate
(Folotyn) ... Peripheral T-cell lymphoma
-
Antitumor antibiotics
Most P-nonspecific EXCEPT Bleomycin (G2-specific)
-
Anthracyclines
Antitumor antibiotics - red pee!
-
Anthracendedione
Antitumor antibiotics - mitoxantrone & bleomycin
-
Daunorubicin
(DaunoXome - liposomal form) ALL
-
Doxorubicin
(Adriamycin, Hydroxydaunorubicin, Adria) BR
-
Liposomal doxorubicin
(Doxil) BR
-
-
-
-
-
DNA Topo II Inhibitors
Epipodophyllotoxins - S & G2-specific
-
Etoposide
(VP-16) L Topo II
-
-
Irinotecan
L Topo I .. pre-Tx atropine
-
-
Antimitotic Agents
M-specific microtubules
-
Taxanes
Antimitotic - *taxels
-
Paclitaxel
(Taxol) BR-cremophor
- Protein-bound Paclitaxel
- (Abraxane) BR
-
-
-
Vinca Alkaloids
Antimitotix - vin*
-
Vinblastine
(VLB, Velban) P
-
Vincristine
(VCR, Oncovin) P
-
-
-
-
Platinum Complex
P-nonspecific
-
Cisplatin
(CDPP, Platinol) L
-
-
Oxaliplatin
(Eloxatin) CR
-
Asparaginase
(Elspar) ALL
-
Pegaspargase
(Oncospar) ALL
-
Arsenic Trioxide
(Trisenox) AML M3 / APML ... induce apoptosis
-
Tretinoin
(All-trans-retinoic acids ATRA) AML M3
-
Antiestrogens BR
SERMS Breast antagonism + Bone agonism
-
-
Toremifene
(Farestron) BR
-
Raloxifene
(Evista) BR - only prevent
-
Fulvestrant
(Faslodex) BR - pure antiestrogen
-
Aromatase Inhibitors
Lowers estrogen /SAFER /POST-MENUPAUSAL /OSTEOPOROSIS
-
Anastrozole
(Arimidex) BR
-
-
Exemestane
(Aromasin) BR / steroidal
-
GnRH LR-RH *Analog*
Increases LR-RH /(-) Feedback /Lowes LH, Testosterone, Estrogen
-
-
-
-
-
GnRH LH-RH *Antagonist*
1st Line - NO FLARING
-
Degarelix
(Firmagon) BR, P
-
Antiandrogens P
Blocks only androgen receptors /not as good as GnRH LH-RH Antagonist
-
-
-
-
Abiraterone
(Zytiga) P ... CYP17 androgen synthesis inhibitor
-
Ketoconazole
(Nizoral) P ... Salvage CYP17 androgen synthesis inhibitor
-
Medroxyprogesterone
(Provera, depo-provera) P
-
-
Testolactone
(Teslac) BR "last line androgen Tx"
-
Fluoxymesterone
(Halotestin) BR "last line androgen Tx"
-
Aminoglutethimide
(Cytadren) Cushing�s Syndrome ... adrenal steroid inhibitor
-
-
-
Denileukin
T-cell Lymphoma CD25
-
Monoclonal antibodies
NO BONE MARROW SUPPRESSION - but have INFUSION REACTION
-
Trastuzumab
(Herceptin) BR: HER-2/neu (ERB-B2)
-
Bevacizumab
(Avastin) L: Vascular Endothelial Growth Factor (VEGF)
-
Alemtuzumab
(Campath) ALL: CD52
-
Rituximab
(Rituxan) LM/NHL: CD20
-
Cetuximab
(Erbitux): ERB-B1 / EGFR Inhibitor
-
Panitumumab
(Vectibix): ERB-B1 / EGFR Inhibitor
-
-
Ipilimumab
(Yervoy): CTLA-4 ... fully human immunoglobulin G
-
Tyrosine Kinase Inhibitors
MUST enter cell to work, PO dosage, *NO BMS*
-
Lapatinib
(Tykerb) BR ... Her2/neu inhibitor
-
Erlotinib
(Tarceva) L ... associated with EGFR
-
Crizotinib
(Xalkori) ... associated with ALK
-
Imatinib
(Gleevec) CML ... Philadelphia chromosome BCR-ABL
-
Dasatinib
(Sprycel) CML ... Philadelphia chromosome BCR-ABL
-
Nilotinib
(Tasigna) CML ... Philadelphia chromosome BCR-ABL
-
Bortezomib
(Velcade) MM: 26S Proteasome inhibitor
-
Sipuleucel-T
(Provenge) P: Immune response targeted against PAP antigen /Prostate cancer 'vaccine'
|
|