ONCO Brand Generic.txt

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Author:
mulderguy
ID:
162934
Filename:
ONCO Brand Generic.txt
Updated:
2012-07-18 02:59:49
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All cancer drugs
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Description:
generic brand disease class
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  1. Alkylating Agents
    P-nonspecific
  2. Cyclophosphamide
    (Cytoxan, CTX) BR, L, ALL
  3. ifosfamide
    (Ifex) L
  4. Mechlorethamine
    LM
  5. Melphalan
    MM
  6. Estramustine
    (Emcyt) P
  7. Carmustine
    MM, LM
  8. Lomustine
    LM
  9. Busulfan
    CML
  10. Dacarbazine
    LM
  11. Procarbazine
    LM
  12. Antimetabolites
    S-phase specific
  13. fluorouracil
    (5-FU, Adrucil) BR
  14. Capecitabine
    (Xeloda) BR ... prodrug of 5-FU
  15. Cytarabine
    (Ara-C) AML
  16. Gemcitabine
    L
  17. 6-mercaptopurine
    AML
  18. Fludarabine
    ALL ... analog of 6-MP
  19. 6-thioguanine
    AML
  20. Cladribine
    ...Hairy cell leukemia
  21. Methotrexate
    (MTX, Rheumatrex, Trexall) BR
  22. Pemetrexed
    (Alimta) L
  23. Pralatrexate
    (Folotyn) ... Peripheral T-cell lymphoma
  24. Antitumor antibiotics
    Most P-nonspecific EXCEPT Bleomycin (G2-specific)
  25. Anthracyclines
    Antitumor antibiotics - red pee!
  26. Anthracendedione
    Antitumor antibiotics - mitoxantrone & bleomycin
  27. Daunorubicin
    (DaunoXome - liposomal form) ALL
  28. Doxorubicin
    (Adriamycin, Hydroxydaunorubicin, Adria) BR
  29. Liposomal doxorubicin
    (Doxil) BR
  30. Idarubicin
    AML
  31. Epirubicin
    BR
  32. Mitoxantrone
    P
  33. Bleomycin
    LM
  34. DNA Topo II Inhibitors
    Epipodophyllotoxins - S & G2-specific
  35. Etoposide
    (VP-16) L Topo II
  36. Teniposide
    L Topo II
  37. Irinotecan
    L Topo I .. pre-Tx atropine
  38. Topotecan
    L Topo I
  39. Antimitotic Agents
    M-specific microtubules
  40. Taxanes
    Antimitotic - *taxels
  41. Paclitaxel
    (Taxol) BR-cremophor
  42. Protein-bound Paclitaxel
    (Abraxane) BR
  43. Docetaxel
    (Taxotere) BR
  44. Cabazitaxel
    (Jevtana) P
  45. Vinca Alkaloids
    Antimitotix - vin*
  46. Vinblastine
    (VLB, Velban) P
  47. Vincristine
    (VCR, Oncovin) P
  48. Vinorelbine
    P
  49. Ixabepilone
    (Ixempra) BR
  50. Eribulin
    (Halaven) BR
  51. Platinum Complex
    P-nonspecific
  52. Cisplatin
    (CDPP, Platinol) L
  53. Carboplatin
    L
  54. Oxaliplatin
    (Eloxatin) CR
  55. Asparaginase
    (Elspar) ALL
  56. Pegaspargase
    (Oncospar) ALL
  57. Arsenic Trioxide
    (Trisenox) AML M3 / APML ... induce apoptosis
  58. Tretinoin
    (All-trans-retinoic acids ATRA) AML M3
  59. Antiestrogens BR
    SERMS Breast antagonism + Bone agonism
  60. Tamoxifen
    (Nolvadex) BR
  61. Toremifene
    (Farestron) BR
  62. Raloxifene
    (Evista) BR - only prevent
  63. Fulvestrant
    (Faslodex) BR - pure antiestrogen
  64. Aromatase Inhibitors
    Lowers estrogen /SAFER /POST-MENUPAUSAL /OSTEOPOROSIS
  65. Anastrozole
    (Arimidex) BR
  66. Letrozole
    (Femara) BR
  67. Exemestane
    (Aromasin) BR / steroidal
  68. GnRH LR-RH *Analog*
    Increases LR-RH /(-) Feedback /Lowes LH, Testosterone, Estrogen
  69. Goserelin
    (Zoladex) BR
  70. Leuprolide
    (Lupron) P
  71. Triptorelin
    (Trelstar) P
  72. Histrelin
    (Vantas) P
  73. GnRH LH-RH *Antagonist*
    1st Line - NO FLARING
  74. Degarelix
    (Firmagon) BR, P
  75. Antiandrogens P
    Blocks only androgen receptors /not as good as GnRH LH-RH Antagonist
  76. Bicalutamide
    (Casodex) P
  77. Flutamide
    (Eulixin) P
  78. Nilutamide
    (Nilandron) P
  79. Abiraterone
    (Zytiga) P ... CYP17 androgen synthesis inhibitor
  80. Ketoconazole
    (Nizoral) P ... Salvage CYP17 androgen synthesis inhibitor
  81. Medroxyprogesterone
    (Provera, depo-provera) P
  82. Megestrol
    (Megace) P
  83. Testolactone
    (Teslac) BR "last line androgen Tx"
  84. Fluoxymesterone
    (Halotestin) BR "last line androgen Tx"
  85. Aminoglutethimide
    (Cytadren) Cushing�s Syndrome ... adrenal steroid inhibitor
  86. Interferon
    CML
  87. Interleukin-2
    Melanoma
  88. Denileukin
    T-cell Lymphoma CD25
  89. Monoclonal antibodies
    NO BONE MARROW SUPPRESSION - but have INFUSION REACTION
  90. Trastuzumab
    (Herceptin) BR: HER-2/neu (ERB-B2)
  91. Bevacizumab
    (Avastin) L: Vascular Endothelial Growth Factor (VEGF)
  92. Alemtuzumab
    (Campath) ALL: CD52
  93. Rituximab
    (Rituxan) LM/NHL: CD20
  94. Cetuximab
    (Erbitux): ERB-B1 / EGFR Inhibitor
  95. Panitumumab
    (Vectibix): ERB-B1 / EGFR Inhibitor
  96. Denosumab
    (Xgeva): RANKL
  97. Ipilimumab
    (Yervoy): CTLA-4 ... fully human immunoglobulin G
  98. Tyrosine Kinase Inhibitors
    MUST enter cell to work, PO dosage, *NO BMS*
  99. Lapatinib
    (Tykerb) BR ... Her2/neu inhibitor
  100. Erlotinib
    (Tarceva) L ... associated with EGFR
  101. Crizotinib
    (Xalkori) ... associated with ALK
  102. Imatinib
    (Gleevec) CML ... Philadelphia chromosome BCR-ABL
  103. Dasatinib
    (Sprycel) CML ... Philadelphia chromosome BCR-ABL
  104. Nilotinib
    (Tasigna) CML ... Philadelphia chromosome BCR-ABL
  105. Bortezomib
    (Velcade) MM: 26S Proteasome inhibitor
  106. Sipuleucel-T
    (Provenge) P: Immune response targeted against PAP antigen /Prostate cancer 'vaccine'

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