Blood

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Anonymous
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163669
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Blood
Updated:
2012-07-23 19:18:34
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Anatomy 2nd long
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Blood
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  1. most abundant plasma protein; made in the liver; maintains the osmotic pressure of the blood
    albumin
  2. plasma protein that functions as transport factors; coagulation factors; also made in the liver
    alpha and beta globulins
  3. plasma protein that functions as antibodies; it is made by the lymphocytes
    gamma-globulin
  4. plasma protein that serve as factors for inflammation and destruction of microorganisms
    complement proteins
  5. the largest plasma protein; polymerizes as insoluble cross-linked fibers
    fibrinogen
  6. diameter of erythrocyte
    7.5um
  7. thickness of erythrocyte(side)
    2.6um
  8. thickness of erythrocyte(center)
    0.75um
  9. mature type of these cell lacks nuclei
    erythrocyte
  10. carries oxygen binding protein(hemoglobin)
    erythrocyte
  11. gives erythrocytes large surface-to-volume ratio to help facilitate gas exchange
    biconcave shape
  12. erythrocyte count(female)
    3.9-5.5 million/uL
  13. erythrocyte count(male)
    4.1-6 million/uL
  14. condition with decreased numbers of erythrocyte
    anemia
  15. condition with increased number of erythrocyte
    polycythemia or erythrocytosis
  16. condition in which the erythrocyte has >9um in diameter
    macrocyte
  17. condition in which the erythrocyte has <6um in diameter
    microcytes
  18. presence of increased percentage of erythrocytes with great variation in size
    anisocytosis
  19. plasma composition
    • 92% water
    • 7% proteins
    • 1%others
  20. protein composition in plasma
    • 58% albumin
    • 37% globulin
    • 4% fibrinogen
    • 1% regulatory proteins
  21. normal value for erythrocyte count
    4.2 - 6.2 million/cubic millimeter
  22. components of buffy coat
    plate lets and leukocytes
  23. normal value of platelets
    130,000 - 400,000/cubic millimeter
  24. differential leukocyte count for basophil
    0.5-1%
  25. differential leukocyte count for eosinophil
    2-4%
  26. differential leukocyte count for neutrophil
    60-70%
  27. differential leukocyte count for lymphocyte
    20-25%
  28. differential leukocyte count for monocyte
    3-8%
  29. membrane proteins found in erythrocyte that function as anion transporter and antigenic sites that form the basis for blood typing
    band 3 protein and glycophorin A
  30. forms a  lattice reinforcing the membrane
    spectrin
  31. anchors the lattice to band 3 proteins
    ankyrin
  32. permits the membrane and cell flexibility required for passage through capillaries and important for the normal low viscosity of blood
    spectrin and ankyrin
  33. fills the erythrocyte cytoplasm; tetrametric; oxygen-binding protein
    hemoglobin
  34. oxygen + hemoglobin
    oxyhemoglobin
  35. carbon diaxode + hemoglobin
    carbaminohemoglobin
  36. percentage of erythrocyte in the blood
    hematocrite
  37. lies between the plasma and the erythrocytes
    buffy coat
  38. disease characterized by mutation of beta-chain of hemoglobin;GAA changed to GV(valine)A
    sickle cell disease
  39. decreased normal blood concentrations of hemoglobin; caused by blood loss; decreased production of erythrocyte; iron deficiency
    anemia
  40. loss of ucleus and all organelles of an erythrocyte before the cells are released by bone marrow into the circulation
    erythrocyte differentiation
  41. formation of erythrocyte that is formed because of an increase in surface tension
    rouleaux formation
  42. type of metabolic pathway mature erythrocyte relies on
    anaerobic glycolysis
  43. lifespan of RBC
    120 days
  44. organs that removes senescent or worn-out erythrocytes
    spleen, liver, and bone marrow
  45. key players in defense against invading microorganism
    leukocytes
  46. basophil, eosinophil, neutrophil; has 2 or more lobes; has 2 types of granules
    granulocyte
  47. granules tat bind neutral, basic or acidic stains; very small
    specific granules
  48. granules that are specialized lysosomes, stain darkly present at some level in leukocytes
    azurophilic granules
  49. enzyme that is bactericidal and generates hypochlorite
    myeloperoxidase
  50. bind and produce holes in cell membranes of microorganism
    defensins
  51. dissolves bacterial cell wall components
    lysozyme
  52. appears to have a single nucleus; has azurophilic granules; contains nonspecific granules
    agranulocytes
  53. trigger loosening of intercellular junctions in the endothelial cells
    cytokines
  54. process where leukocytes sends extensions into the new intercellular openings, migrate ut of the vunules, head directly for bacterial cells
    diapedesis
  55. process of attraction of neutrophils to bacteria that involves chemical mediators
    chemotaxis
  56. appears to have 2-5 lobes; lives 6-7 hours in the blood and 1-4 days in other tissues; circular when inactive; contains glycogen
    neutrophils
  57. has vacuoles(phagosomes); engulf by phagocytosis; pH 5.0
    neutrophils
  58. neutrophils that hs >5 segments indicates what disease
    megaloblastic anemia
  59. drum-stick shaped structure in the neutrophils; indicates sexuality(female)
    barr-bodies
  60. has a bilobed nucleus; has large rod specific granules; fights parasites; phagocytize antigen-antibody complexes and modulate inflammatory responses; has large refractile pink-orange-red granules
    eosinophils
  61. proteins responsible for the red-orange-pink staining of the eosinophils
    major basic protein
  62. nucleus is divided into two or more irregular lobes; has obscured and blue-black granules; has eosinophilic chemotactic factors; secretes histamin and heparin
    basophil
  63. has spherical nuclei; T cell, B cell and NK cell
    lymphocytes
  64. leukocyte that can return after diapedesis
    lymphocyte
  65. cell mediated immunity
    t-cell
  66. humoral immunity
    b-cell
  67. programmed to kill cancer cells; directly acts
    natural killer cells
  68. has large, oval, kidney-shaped nucleus; basophilic cytoplasm; has small azurophilic granules
    monocyte
  69. differentiation of monocyte; eat dying and old cell
    macrophage
  70. promote clotting; repair of minor tears or leaks in the walls of blood vessels; 10 day lifespan
    platelets
  71. lightly stained part of platelet
    hyalomere
  72. darker staining granule in the platelet
    granulomere
  73. helps maintain the platelet's ovoid shape
    marginal bundle of microtubules and microfilaments
  74. derived from ER and stores calcium; facilitates rapid exocytosis
    dense tubular system 
  75. facilitates platelet uptake of fibrinogen and serotonin of plasma; facilitates rapid exocytosis
    open cannalicular system
  76. role of platelet that allow platelet aggregation to collagen via collagen binding protein
    primary aggregation
  77. 1st step to stop bleeding
    platelet plug
  78. platelet plig release adhesive glycoprotein and ADP to induce platelet aggregation and increase the size of platelet plug
    seconday aggregation
  79. fibrinogen and von willebrand factor promote cascade; fibrin to blood clot thrombus
    blood coagulation
  80. interaction of actin and myosin in the clot
    clot retraction
  81. action of proteolytic enzyme plasmin through local action of plasminogen activators; plasminogen from plasma
    clote removal
  82. possess a variety of membrane-bound granules and a sparse population of mitochondria and glycogen particles; has mitochondira and glycogen particles
    central granulomere
  83. granules in the central granulomere that has platelet derived growth factor
    alpha granules
  84. granules in the central granulomere that has ATP, ADP, and serotonin
    delta granules
  85. granules in the central granulomere that has lysosomal enzymes
    lambda granules
  86. disease condiiton with decreased blood coagulation
    hemophilia
  87. clotting factor that has a defect in hemophilia A
    factor VII
  88. clotting factor that has a defect in hemophilia B
    factor IX

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