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T/F: Women with an intact uterus going through menopause must be treated with both estrogen and progestin.
TRUE. Women who have had a hysterectomy are treated with unopposed estrogen only.
What are the estrogen-progestin producst available?
What is the role of Estrogen in Contraceptives? What is the role Progestin?
- Estrogen: prevents development of dominant follicle by suppressing FSH.
- Progesetin: blocks ovulation. Causes production of thick cervical mucus and atrophy of endometrium.
What are extended cycle OCs?
They delay menstruation. Occurs around every 3 months or not at all.
- Loestrin-24 FE
Which OC is a continuous-cycle OC?
Which contraceptive is in a transdermal system?
Which contraceptive is a subdermal rod? An injection? An IUD?
- Depo-Provera (medroxyprogesterone)
- Mirena (x 5 years)
SE such as breast tenderness, fullness, nausea, blaoting, HTN, skin discoloration (melasma), HA are usually associated with ______ excess.
SE such as acne, depression, irritability, hypomenorrhea, increased appetite and weight agin, fatigue, constipation is usually associated with ____________ excess.
Early breakthrough bleeding is associated with _________ deficiency, while late breakthrough bleedining is associated with _________ deficiency.
What is Type I and Type II osteoporosis?
- Type I: Postmenopausal (most common)
- Type II: Age related
After completing a DEXA scan, a T score of -1.0 to -2.5 standard deviations below young adult mean is considered to be __________.
After completing a DEXA scan, a T score below -2.5 standard deviations below young adult mean is considered to be __________.
Calcium Citrate (24% calcium content)
Calcium Carbonate (40% calcium content)
- Viactiv chews
- Mylanta Supreme liquid
Calcium phosphate tribasic (39% calcium content)
What is the MOA of bisphosphonates?
Bind to bone (hydroxyapatite) and incorporate into bone to increase and stablize bone mass. They also inhibit osteoclasts have have very long half-life in the bone.
Alendronate - brand/dosing?
Prevention: 5 mg/day or 35mg/wk
Treatment = x 2 of prevention
Risedronate - brand/dosing?
- Prevention: 5 mg/day
- Treatment: 5 mg/day
- OR 35 mg/wk
- OR75 mg/day x 2 days/month
- OR 150 mg/month
Ibandronate - brand/dosing?
2.5 mg/day, 150 mg/month, 3 mg IV Q3 months
Zoledronic Acid - brand/dosing?
5 mg IV infusion over 15 minutes QYEAR
Miacalcin - INTRANASAL - qd alternating nostrils or SQ or IM QOD
*Calcitonin inhibits bone resorption by binding to osteoclast receptors.
Teriperatide (PTH hormone)
Injection daily - increases rate of bone formation by stimulating osteoblasts.
60 mg daily