Lecture 29.txt

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epaynich
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Lecture 29.txt
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2010-04-27 15:18:36
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Micro Lecture
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Micro 221 Lecture 29
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  1. Broad Activity Spectrum
    Kills a wide variety of organism
  2. Narrow Activity spectrum
    kills a specific organism
  3. Bacteriostatic
    prevents growth of an organism
  4. Bacteriolytic
    lyses bacteria
  5. Bacteriocidal
    kills the organism
  6. Therapeutic index
    ratio of toxic dose / theraputic dose
  7. 1st generation
    first release of antibiotic; has G+ action
  8. 2nd generation
    G+ and G- action but not psedomonas
  9. 3rd generation
    G- including pseudomonas
  10. 4th generation
    slightly expanded spectrum
  11. Cell wall active antibiotics
    target peptidoglycan
  12. Beta Lactams
    Prevent peptidoglycan cross linking
  13. Penicillins
    Beta Lactam that prevents peptidoglycan cross linking
  14. Cephalosporins
    Beta lactam that prevents peptidoglycan cross linking
  15. Vancomycin
    prevents peptidoglycan transglycosylation
  16. Bacitracin
    Prevents monomers of PG transport across membrane which prevents PG synthesis
  17. Fluoroquinolones
    inhibit DNA gyrase to prevent replication
  18. Rifamycins
    inhibit RNA polymerase to prevent transcription
  19. Cell Membrane Disruptors
    Not much difference between their membrane and ours so difficult to make
  20. Polymyxins
    have low theraputic index because we have a membrane too
  21. Cubicin
    collapses PMF of bacteria
  22. Folate inhibitors
    bacteria make own folic acid by PABA to make nucleotides
  23. Sulfa drugs
    structurally similar to PABA and inhibit the synthesis
  24. Trimethoprim
    inhibit folic acid synthesis
  25. Protein Synthesis Inhibitors
    work on ribosome or tRNA to block protein synthesis
  26. Amantadine
    targets uncoating step of virus; collapses the change in pH of the endocytic vessicle
  27. Rimantadine
    targets uncoating step of virus
  28. Nucleoside Analogs
    competative inhibitors of DNA polymerase or RNA polymerase
  29. Reverse Transcriptase inhibitor
    Kills retroviruses by blocking reverse transcriptase
  30. Protease Inhibitors
    inhibits the cutting up of polyprotein
  31. Neuraminidase inhibitors
    doesn't allow release of virus during budding
  32. ergosterol
    in fungal plasma membrane
  33. polyenes
    topical inhibition of ergosterol
  34. Azoles
    antifungal ergosteral inhibition
  35. Echinocandins
    target different linkage of fungal cell wall
  36. Griseofulvin
    inhibits fungal cell division; low theraputic index
  37. Metronidazole
    target flagyl in intestinal infections
  38. Chloroquine
    treats malaria; becoming resistant
  39. Artemisinin
    comes from a plant; treats malaria
  40. Ivermectin
    treats worms in tissues
  41. Piperazine
    treats intestinal worms
  42. Minimum inhibitory concentration
    minimum dilution that is effective
  43. Kirby bauer test
    uses filter paper to measure zone of killing
  44. E-test
    measures MIC and tests multiple antimicrobiols
  45. Efflux Pump
    pumps antibacterial out once it enters
  46. F-Plasmid
    can be transmitted from one cell to another through horizontal gene transfer
  47. F' plasmid
    part that leaves Hfr; f plasmid w/ bacterial gene
  48. R plasmid
    F plasmids with multiple resistance genes

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