Rheumatoid Arthritis, Osteoarthritis, Gout

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Author:
evelngo
ID:
164511
Filename:
Rheumatoid Arthritis, Osteoarthritis, Gout
Updated:
2012-07-30 22:11:13
Tags:
RA OA GOUT
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Description:
RA, OA, GOUT
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  1. T/F: NSAIDs help by reducing pain and swellin, but they do NOT inhibit joint destruction or alter the course of the disease.
    TRUE
  2. Diclofenac
    Voltaren
  3. Etodolac
    Lodine
  4. Nabumetone
    Relafen
  5. Tolmetin
    Tolectin
  6. Sulindac
    Clinoril
  7. Fenoprofen
    Nalfon
  8. Flurbiprofen
    Ansaid
  9. Ibuprofin
    Motrin
  10. Ketoprofen
    Orudis
  11. Naproxen
    Naprosyn
  12. Oxaprozin
    Daypro
  13. Meclofenamate
    Meclomen
  14. Piroxicam
    Feldene
  15. Celecoxib
    Celebrex
  16. What are DMARDs?
    Disease-modifying antirheumatic drugs - ability to reduce or prevent joint damage and preserve joint integrity and function
  17. Hydroxychloroquine
    Plaquenil - inhibits IL-1 = decreased chemotaxis and phagocytosis. Causes retinal damage, rash, skin pigment changes, and peripheral neuropathy.
  18. Sulfasalazine
    Azulfidine - sulfapyridine metabolite inhits endothelial cell proliferation, ROS, and cytokines. Effects are quicker than Plaquenil. May cause GI intolerance, leukopenia and thrombocytopenia
  19. Methotrexate
    Rheumatrex - interferes with DNA synthesis - take only ONCE a WEEK. Teratogen (category X). May cause liver damage, leukopenia, thrombocytopenia, stomatitis.
  20. Leflunomide
    Arava - inhibits dihydroorotate dehydrogenase and ahs antiproliferative activity. Teratogen (Category X), diarrhea, alopecia
  21. Pencillamine
    Cuprimine - MOA unknown. May cause thrombocytopenia, leukopenia, proteinuria, stomatitis
  22. List biologics used in treatment of RA
    • Anakinra (Kineret)
    • Etanercept (Enbrel)
    • Infliximab (Remicade)
    • Adalimumab (Humira)
    • Abtacept (Orencia)Rituximab (Rituxan)
  23. Symptoms of RA may include:
    • Multiple joint pain
    • Morning stiffness (gel-like sensation)
    • Generalized fatigue
  24. Osteoarthritis is usually characterized by:
    • Pain in weight bearing joints
    • Morning stiffness that is relatively short in duration in comparison to RA - generally resolves with movement.
    • Crepitus is common (crackling noise)
  25. What are the oral drug therapy for OA?
    • APAP
    • NSAIDs
    • Tramadol
  26. What are intra-articular drugs used to treat OA?
    • Glucocorticoids
    • Hyaluronan (Orthovisc)
  27. What are topical meds used to treat OA?
    • Capsaicin
    • Methyl salicylate
  28. What three drug classes are generally used in the treatment of an acute gouty arthritis attack?
    • Colchicine - 3 tabs within 1st hour
    • NSAIDs
    • Corticosteroids
  29. Which drugs are used for gout prophylaxis?
    • Probenecid (Benemid)
    • Sulfinpyrazone (Anturane)
    • Allopurinol (Zyloprim)
    • Febuxostat (Uloric)
  30. Probenecid
    Benemid - Uricosuric agent that promotes excretion of uric acid
  31. Sulfinpyrazone
    Anturane - uricosuric that promotes extretion of urice acid
  32. Allopurinol
    Zyloprim - inhibits xanthine oxidase formation --> affects azathioprine and 6-MP
  33. Febuxostat
    Uloric - inhibits xanthine oxidase formation

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