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What is the dose, strength, and frequency of PCN G.
IV 2-3 MU IV q4h
What is the dose, strength and frequency of PCN VK?
PO 250-500 mg po q6h
What is the spectrum of natural penicillins (G and VK)?
- Penicillin-susceptible streptococcus: S. pyogenes (Group A strep) and S. viridans (endocarditis)
- PCN-susceptible: S. pneumoniae
- Upper airway anaerobes: Peptococcus and peptostreptococcus
What are the clinical uses of natural penicillins (G and VK)?
- Upper respiratory infections: susceptibility testing necessary for S. pneumoniae
- Bacteremias (various strep)
- Dental infections (various strep)
- Endocarditis (Strep. viridans)
What are penicillinase-resistant PCNs used for and examples?
- Use only for staph infections, such as methicillin-susceptible staph.
- Nafcillin: IV 2g IV q4h
- Oxacillin: IV
- Cloxacillin: PO
- Dicloxacillin: PO 250-500 mg po q6h
- Methicillin: IV (off the market)
What are the clinical uses of anti staph penicillins, such as nafcillin and dicloxacillin?
Staph infections (MSSA and MSSE), such as cellulitis, osteomyelitis, infective endocarditis.