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what are the forms of insulin that are available iv?
llispro and regular
which insulin has no peak?
glargine insulin - so there is no chance of hypoglycemia
what is the MOA of insulin?
binds to transmembrane receptor activating tyrosine kinase to phosphorylate tissue specific substrate
name ketoacids ?
acetate(fruity smell) , acetoacetate . beta hydroxybutyrate
what is the MOA of sulfonylureas ?
name the drugs that block and open ATP dependent potassium channels ?
open - minoxidil and diazepoxide - cause hyperglycemia
close - sulfonylureas - causes hypoglycemia
why are metformins called as glucophage?
because it causes the tissues to eat up glucose , because it causes increased sensitivity to insulin
what is the MOA of metformin?
it increases tissue sensitivity to insulin and decreases hepatic gluconeogenesis
which hypoglycemic causes euglycemia?
metformin - reduces postprandial hyperglycemia but doesnot cause hypoglycemia
name alpha glycosidases inhibitors ?
acarbose and miglitol
pio and rosi glitazones
what is incretin ?
they are released from small intestine and increase the secretion of insulin by acting on beta cells. it is also called as GLP
name the drugs acting on GLP?